Advantage 40 mg Spot-on Solution for Small Cats, Small Dogs and Pet Rabbits

Re-infestation from emergence of new fleas in the environment may continue to
occur for six weeks or longer after treatment is initiated. To aid reduction in
environmental challenge, the additional use of a suitable environmental treatment
against adult fleas and their developing stages is recommended. In order to reduce
further the environmental challenge, it is recommended that all dogs, cats and
rabbits in the household are treated, as necessary, with an appropriate product.
Treatment of nursing bitches and queens controls flea infestations on both dam and
offspring.
The veterinary medicinal product remains effective if the animal becomes wet, for
example after exposure to heavy rain or after swimming (dogs). However, re-
treatment may become necessary, depending on the presence of fleas in the
environment. In these cases do not treat more frequently than once weekly.
Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy.
The decision to use the product should be based on confirmation of the parasitic
species and burden, or of the risk of infestation based on its epidemiological
features, for each individual animal.
The possibility that other animals in the same household can be a source of re-
infection with biting lice (dogs) should be considered, and these should be treated
as necessary with an appropriate product.

Special precautions for safe use in the target species:
This veterinary medicinal product is for topical use and should not be administered
orally.
Apply only to undamaged skin.
Care should be taken to avoid the contents of the tube coming into contact with the
eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Any collar should be removed prior to application of the veterinary medicinal
product. Prior to re-fitting the collar, the treated area should be visually assessed to
ensure it is dry.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Keep stored tubes in the original packaging until ready to use. In order to prevent
children from getting access to used tubes, dispose of used tubes immediately.
People with known hypersensitivity to imidacloprid should avoid contact with the
veterinary medicinal product.
This product contains benzyl alcohol and may cause sensitisation or transient skin
reactions (e.g. irritation, tingling).
Avoid contact between the veterinary medicinal product and skin, eyes or mouth.
Do not massage the application site.
If the veterinary medicinal product gets into eyes, flush thoroughly with water.
If skin or eye irritation persists or the veterinary medicinal product is accidentally
swallowed, seek medical advice immediately and show the package leaflet or the
label to the physician.
Do not eat, drink or smoke during application.
Wash hands thoroughly after use.
Wash off any skin contamination with soap and water.
After application, do not stroke or groom treated animals until the application site is
dry (typically within an hour or so). It is therefore recommended that animals are not
treated during the day, but should be treated during the early evening, and that
recently treated animals are not allowed to sleep with owners, especially children.
Special precautions for the protection of the environment:
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on aquatic
organisms, treated dogs should not be allowed to enter surface water for 48 hours
after treatment.
Other precautions:
The solvent in this veterinary medicinal product may stain or damage certain
materials including leather, fabrics, plastics and finished surfaces. Allow the
application site to dry before permitting contact with such materials.