Advantage 250 Spot-on Solution for Dogs

Unnecessary use of antiparasitics or use deviating from the instructions given in the
SPC may increase the resistance selection pressure and lead to reduced efficacy. The
decision to use the veterinary medicinal product should be based on confirmation of the
parasitic species and burden, or of the risk of infestation based on its epidemiological
features, for each individual animal.
The possibility that other animals in the same household can be a source of re-infection
with fleas and biting lice should be considered, and these should be treated as
necessary with an appropriate product.
Re-infestation from emergence of new fleas in the environment may continue to occur
for six weeks or longer after treatment is initiated. More than one treatment may
therefore be required, depending on the level of fleas in the environment. To aid
reduction in environmental challenge, the additional use of a suitable environmental
treatment against adult fleas and their developing stages is recommended, especially of
the animal's basket, bedding and regular resting areas such as carpets and soft
furnishings. In order to reduce further the environmental challenge, it is recommended
that all dogs in the household are treated. Treatment of nursing bitches controls flea
infestations on both dam and offspring.
The veterinary medicinal product remains effective if the animal becomes wet, for
example after swimming or exposure to heavy rain. However, in cases of frequent
swimming or bathing re-treatment may become necessary, depending on the presence
of fleas in the environment. In these cases do not treat more frequently than once
weekly.

Special precautions for safe use in the target species:
This veterinary medicinal product is for topical use and should not be administered
orally.
Care should be taken to avoid the contents of the pipette coming into contact with the
eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This veterinary medicinal product contains benzyl alcohol and may cause skin
sensitisation or transient skin reactions in rare cases (for example, irritation, tingling).
People with known hypersensitivity to imidacloprid and benzyl alcohol should avoid
contact with the veterinary medicinal product .
Avoid contact between the veterinary medicinal product and skin, eyes or mouth. Do not
massage the application site.
Do not eat, drink or smoke during application.
Wash off any skin contamination with soap and water.
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If the veterinary medicinal product gets into eyes accidentally, the eyes should be
thoroughly flushed with water. If skin or eye irritation persists, or the veterinary
medicinal product is accidentally swallowed, seek medical advice immediately and show
the package leaflet or the label to the physician.
After application, do not stroke or groom animals until application site is dry.
Wash hands thoroughly after use.
Special precautions for the protection of the environment:
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on aquatic
organisms, treated dogs should not be allowed to enter surface water for 48 hours after
treatment. See also section 5.5.
Other precautions:
The solvent in this veterinary medicinal product may stain certain materials including
leather, fabrics, plastics and finished surfaces. Allow the application site to dry before
permitting contact with such materials.