Piriton (Chlorphenamine) vs Apoquel
A detailed comparison of Piriton (Chlorphenamine) and Apoquel for dogs. Which is the better choice? We compare ingredients, dosing, price, and side effects.
Piriton (Chlorphenamine)
A first-generation antihistamine sometimes used in dogs for mild allergic reactions, itching, and insect bites. Available over the counter for humans.
Apoquel
Oclacitinib — a prescription JAK inhibitor specifically designed for canine allergic dermatitis. The most prescribed anti-itch drug for dogs.
Save on Piriton (Chlorphenamine) or Apoquel at a UK pharmacy
UK registered pharmacies dispense the same prescription medications as your vet, often for less. Ask your vet for a written prescription, then fill it online.
Affiliate links to The Pharm Pet Co., a UK registered veterinary pharmacy. We may earn a small commission, at no extra cost to you. Always follow your vet's guidance on medication choice and dosing.
Side-by-Side Comparison
| Feature | Piriton (Chlorphenamine) | Apoquel |
|---|---|---|
| Active Ingredient | Chlorphenamine maleate | Oclacitinib |
| Form | Tablet or liquid | Tablet |
| Frequency | Two to three times daily | Once daily (after loading) |
| Species | Dogs | Dogs |
| Price Range | £2–£5/box (OTC) | £45–£90/month |
Key Differences
Effectiveness
Apoquel is dramatically more effective — antihistamines only help ~30% of allergic dogs.
Cost
Piriton costs pennies per day; Apoquel costs £1.50–3/day. A 50x+ difference.
Mechanism
Piriton blocks histamine; Apoquel blocks JAK enzymes — a much more targeted anti-itch pathway.
Prescription
Piriton is OTC; Apoquel requires a vet prescription and regular check-ups.
When to use
Try Piriton first for mild cases. If ineffective, Apoquel is the next step.
Pros & Cons
Piriton (Chlorphenamine)
Pros
- Very cheap — available from any online retailer
- No prescription needed
- Safe for mild cases
- Can be used alongside other treatments
Cons
- Much less effective than Apoquel for moderate/severe allergies
- Causes drowsiness
- Antihistamines only help ~30% of allergic dogs
- Short duration — needs multiple daily doses
Apoquel
Pros
- Specifically designed for dogs — far more effective
- Relieves itch within 4 hours
- Proven efficacy in clinical trials
- Once daily dosing after initial loading period
Cons
- Very expensive compared to antihistamines
- Prescription only
- Immunosuppressive (JAK inhibitor)
- Blood monitoring recommended
Compare Prices & Save
Both Piriton (Chlorphenamine) and Apoquel may be cheaper from a licensed online retailer than from your vet. Ask for a written prescription and compare prices.
Important: This comparison is for informational purposes only and is not veterinary advice. Always consult your vet before starting, stopping, or switching your pet's medication. Prices shown are typical UK ranges and may vary by product size, weight band, and retailer.
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
The Pharm Pet Co. — Pet Pharmacy
UK online pet pharmacy. Flea, worm, prescription medications, supplements and pet food. Save vs vet prices.
Pet Care at Pharmacy2U
The UK's largest online pharmacy. Pet wormers, flea treatments, dental and joint care. Free delivery on orders over £30.
VetBox Flea & Worm Protection for Dogs
Vet-founded monthly parasite subscription. Flea, tick and worm protection delivered to your door. Founded by Dr Will Woodley, protecting 30,000+ pets.
We may earn a small commission if you purchase through these links, at no extra cost to you.