NexGard Spectra vs Seresto Collar
A detailed comparison of NexGard Spectra and Seresto Collar for dogs. Which is the better choice? We compare ingredients, dosing, price, and side effects.
NexGard Spectra
Monthly chewable tablet covering fleas, ticks, and intestinal worms including lungworm. An all-in-one oral parasite treatment.
Seresto Collar
Long-lasting flea and tick collar providing continuous protection for up to 8 months with no monthly applications.
Save on NexGard Spectra or Seresto Collar at a UK pharmacy
UK registered pharmacies dispense the same prescription medications as your vet, often for less. Ask your vet for a written prescription, then fill it online.
Affiliate links to The Pharm Pet Co., a UK registered veterinary pharmacy. We may earn a small commission, at no extra cost to you. Always follow your vet's guidance on medication choice and dosing.
Side-by-Side Comparison
| Feature | NexGard Spectra | Seresto Collar |
|---|---|---|
| Active Ingredient | Afoxolaner + Milbemycin Oxime | Imidacloprid + Flumethrin |
| Form | Chewable tablet | Collar |
| Frequency | Monthly | Replace every 8 months |
| Species | Dogs | Dogs |
| Price Range | £8–£18/month | £25–£40/collar (8 months) |
Key Differences
Worm coverage
NexGard Spectra covers intestinal worms and lungworm; Seresto has zero worm activity.
Convenience
Seresto is fit-and-forget for 8 months; NexGard Spectra needs a monthly tablet.
Total annual cost
Seresto is cheaper for flea/tick alone (~£50/year), but add worming (~£30–50/year) and costs are similar to NexGard Spectra (~£96–216/year).
Administration
NexGard Spectra is a chewable tablet; Seresto is a collar. Choose based on what your dog tolerates.
Children
NexGard Spectra has no contact risk; Seresto collar contains pesticides that transfer to fur on contact.
Pros & Cons
NexGard Spectra
Pros
- Covers worms (including lungworm) as well as fleas and ticks
- No collar needed — invisible protection
- Can stop immediately if side effects occur
- Precise dosing by weight band
Cons
- Monthly tablet — more effort than a collar
- Prescription only
- More expensive per year if you add worming costs for Seresto
- Isoxazoline class — rare neurological side effects
Seresto Collar
Pros
- 8 months protection — fit and forget
- Works out very cheap per month (~£3–5/month)
- No oral dosing — great for dogs that refuse tablets
- Water resistant — suitable for swimming dogs
Cons
- No worm coverage at all — need a separate wormer
- Collar must be worn continuously
- Concern if young children frequently handle the dog
- Cannot adjust dose — one approach for all dogs in weight range
Compare Prices & Save
Both NexGard Spectra and Seresto Collar may be cheaper from a licensed online retailer than from your vet. Ask for a written prescription and compare prices.
Important: This comparison is for informational purposes only and is not veterinary advice. Always consult your vet before starting, stopping, or switching your pet's medication. Prices shown are typical UK ranges and may vary by product size, weight band, and retailer.
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
Flea & Tick Treatments for Dogs
Vet-strength flea and tick treatments at pharmacy prices. Frontline, Advocate, Bravecto, Nexgard and more.
Pet Flea Treatments at Pharmacy2U
Frontline, Advantage and own-brand flea treatments at pharmacy prices. Trusted UK pharmacy since 1999.
VetBox Flea & Worm Protection for Dogs
Vet-founded monthly parasite subscription. Flea, tick and worm protection delivered to your door. Founded by Dr Will Woodley, protecting 30,000+ pets.
We may earn a small commission if you purchase through these links, at no extra cost to you.