Gabapentin vs Pregabalin
A detailed comparison of Gabapentin and Pregabalin for dogs. Which is the better choice? We compare ingredients, dosing, price, and side effects.
Gabapentin
An anticonvulsant medication commonly used off-label for neuropathic pain and as an anxiolytic in dogs. Also used as an adjunct to NSAIDs for chronic pain.
Pregabalin
A newer-generation gabapentinoid with stronger binding affinity. Used for neuropathic pain, seizures, and anxiety in dogs. More potent than gabapentin.
Save on Gabapentin or Pregabalin at a UK pharmacy
UK registered pharmacies dispense the same prescription medications as your vet, often for less. Ask your vet for a written prescription, then fill it online.
Affiliate links to The Pharm Pet Co., a UK registered veterinary pharmacy. We may earn a small commission, at no extra cost to you. Always follow your vet's guidance on medication choice and dosing.
Side-by-Side Comparison
| Feature | Gabapentin | Pregabalin |
|---|---|---|
| Active Ingredient | Gabapentin | Pregabalin |
| Form | Capsule or liquid | Capsule |
| Frequency | Two to three times daily | Twice daily |
| Species | Dogs | Dogs |
| Price Range | £5–£15/month | £10–£30/month |
Key Differences
Potency
Pregabalin is 2–6x more potent than gabapentin at the receptor level.
Dosing frequency
Gabapentin typically 2–3 times daily; pregabalin twice daily.
Cost
Gabapentin is much cheaper. Important for long-term chronic pain management.
Consistency
Pregabalin has more predictable absorption and plasma levels.
Availability
Pregabalin is a Schedule 3 controlled substance; gabapentin is not (in the UK for veterinary use).
Pros & Cons
Gabapentin
Pros
- Very affordable — cheap generic available
- Long track record in veterinary use
- Good for neuropathic pain and anxiety
- Liquid form available for small dogs/cats
Cons
- Needs dosing 2–3 times daily
- Can cause sedation and wobbliness
- Variable absorption between doses
- Off-label use (not licensed for dogs)
Pregabalin
Pros
- More potent — lower doses needed
- More consistent absorption
- Twice daily dosing (more convenient)
- May be more effective for severe neuropathic pain
Cons
- More expensive
- Controlled drug (Schedule 3)
- Can cause more pronounced sedation initially
- Off-label use in dogs
Compare Prices & Save
Both Gabapentin and Pregabalin may be cheaper from a licensed online retailer than from your vet. Ask for a written prescription and compare prices.
Important: This comparison is for informational purposes only and is not veterinary advice. Always consult your vet before starting, stopping, or switching your pet's medication. Prices shown are typical UK ranges and may vary by product size, weight band, and retailer.
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
The Pharm Pet Co. — Pet Pharmacy
UK online pet pharmacy. Flea, worm, prescription medications, supplements and pet food. Save vs vet prices.
Pet Care at Pharmacy2U
The UK's largest online pharmacy. Pet wormers, flea treatments, dental and joint care. Free delivery on orders over £30.
VetBox Flea & Worm Protection for Dogs
Vet-founded monthly parasite subscription. Flea, tick and worm protection delivered to your door. Founded by Dr Will Woodley, protecting 30,000+ pets.
We may earn a small commission if you purchase through these links, at no extra cost to you.