Apoquel vs Cytopoint
A detailed comparison of Apoquel and Cytopoint for dogs. Which is the better choice? We compare ingredients, dosing, price, and side effects.
Apoquel
Daily oral tablet (oclacitinib) that rapidly controls itching and inflammation caused by allergic dermatitis. Works by blocking JAK enzymes involved in the itch signal.
Cytopoint
Monthly injection (lokivetmab) given at the vet that neutralises the itch-causing cytokine IL-31. A monoclonal antibody treatment — not a drug in the traditional sense.
Save on Apoquel or Cytopoint at a UK pharmacy
UK registered pharmacies dispense the same prescription medications as your vet, often for less. Ask your vet for a written prescription, then fill it online.
Affiliate links to The Pharm Pet Co., a UK registered veterinary pharmacy. We may earn a small commission, at no extra cost to you. Always follow your vet's guidance on medication choice and dosing.
Side-by-Side Comparison
| Feature | Apoquel | Cytopoint |
|---|---|---|
| Active Ingredient | Oclacitinib (JAK inhibitor) | Lokivetmab (monoclonal antibody) |
| Form | Tablet | Injection (given by vet) |
| Frequency | Twice daily for 14 days, then once daily | Once every 4–8 weeks |
| Species | Dogs | Dogs |
| Price Range | £1.50–£3/day (£45–£90/month) | £50–£120/injection |
Key Differences
Administration
Apoquel is a daily tablet at home; Cytopoint is a monthly injection at the vet.
Speed of relief
Apoquel works within 4 hours; Cytopoint takes 1–3 days.
Immune effects
Apoquel suppresses part of the immune system (JAK pathway); Cytopoint targets only IL-31 (no immune suppression).
Monitoring
Apoquel requires periodic blood tests; Cytopoint does not.
Flexibility
Apoquel can be stopped/started easily; Cytopoint commits you to a monthly vet visit.
Pros & Cons
Apoquel
Pros
- Very rapid itch relief — within 4 hours
- Owner can adjust dose timing
- Can stop and start as needed (e.g. seasonal allergies)
- Available from online online retailers with a prescription
Cons
- Daily tablet — must remember every day
- Can suppress immune function (JAK inhibitor)
- Regular blood monitoring recommended
- Higher infection risk with long-term use
Cytopoint
Pros
- No daily pills — just a monthly vet injection
- Does not suppress the immune system
- No blood monitoring needed
- Very targeted mechanism — fewer systemic side effects
Cons
- Must visit the vet every 4–8 weeks for injection
- Cannot buy online — vet administration only
- More expensive per month for larger dogs
- Takes 1–3 days to reach full effect (slower than Apoquel)
Compare Prices & Save
Both Apoquel and Cytopoint may be cheaper from a licensed online retailer than from your vet. Ask for a written prescription and compare prices.
Important: This comparison is for informational purposes only and is not veterinary advice. Always consult your vet before starting, stopping, or switching your pet's medication. Prices shown are typical UK ranges and may vary by product size, weight band, and retailer.
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
The Pharm Pet Co. — Pet Pharmacy
UK online pet pharmacy. Flea, worm, prescription medications, supplements and pet food. Save vs vet prices.
Pet Care at Pharmacy2U
The UK's largest online pharmacy. Pet wormers, flea treatments, dental and joint care. Free delivery on orders over £30.
VetBox Flea & Worm Protection for Dogs
Vet-founded monthly parasite subscription. Flea, tick and worm protection delivered to your door. Founded by Dr Will Woodley, protecting 30,000+ pets.
We may earn a small commission if you purchase through these links, at no extra cost to you.