Apoquel vs Atopica
A detailed comparison of Apoquel and Atopica for dogs. Which is the better choice? We compare ingredients, dosing, price, and side effects.
Apoquel
Oclacitinib tablets — a JAK inhibitor that rapidly stops itching. The most commonly prescribed oral allergy medication for dogs in the UK.
Atopica
Ciclosporin capsules — an immunosuppressant that controls allergic dermatitis by suppressing the overactive immune response. Takes longer to work but effective for chronic cases.
Save on Apoquel or Atopica at a UK pharmacy
UK registered pharmacies dispense the same prescription medications as your vet, often for less. Ask your vet for a written prescription, then fill it online.
Affiliate links to The Pharm Pet Co., a UK registered veterinary pharmacy. We may earn a small commission, at no extra cost to you. Always follow your vet's guidance on medication choice and dosing.
Side-by-Side Comparison
| Feature | Apoquel | Atopica |
|---|---|---|
| Active Ingredient | Oclacitinib | Ciclosporin (Cyclosporine) |
| Form | Tablet | Soft capsule |
| Frequency | Once daily (after initial 2-week loading) | Once daily (can sometimes reduce to alternate days) |
| Species | Dogs | Dogs |
| Price Range | £1.50–£3/day | £2–£5/day |
Key Differences
Onset
Apoquel works within hours; Atopica takes 4–6 weeks for full effect.
Mechanism
Apoquel blocks JAK enzymes (itch pathway); Atopica broadly suppresses T-cell immunity.
Side effects
Apoquel: increased infections. Atopica: GI upset, gum overgrowth, increased hair growth.
Generics
Atopica has cheaper generics (Sporimmune, Cyclavance); generic Apoquel is not yet widely available.
Best for
Apoquel for rapid relief and flare-ups; Atopica for chronic, long-term management where cost is a factor.
Pros & Cons
Apoquel
Pros
- Very fast — relieves itch within hours
- Well-tolerated by most dogs
- Small tablet — easy to give
- Can be used short-term for flare-ups
Cons
- JAK inhibitor — some immune suppression
- Periodic blood monitoring needed
- Daily dosing required
- Relatively new — less long-term data than ciclosporin
Atopica
Pros
- Decades of use — very well-understood
- Can often reduce to alternate-day dosing once controlled
- Generic versions (Sporimmune) available for savings
- Effective for severe/chronic atopic dermatitis
Cons
- Takes 4–6 weeks to reach full effect
- GI side effects common (vomiting, diarrhoea) initially
- Broader immunosuppression than Apoquel
- Must be given on an empty stomach
Compare Prices & Save
Both Apoquel and Atopica may be cheaper from a licensed online retailer than from your vet. Ask for a written prescription and compare prices.
Important: This comparison is for informational purposes only and is not veterinary advice. Always consult your vet before starting, stopping, or switching your pet's medication. Prices shown are typical UK ranges and may vary by product size, weight band, and retailer.
Alternative options to consider
Retailers we earn a commission from. It costs you nothing and never changes what we show.
The Pharm Pet Co. — Pet Pharmacy
UK online pet pharmacy. Flea, worm, prescription medications, supplements and pet food. Save vs vet prices.
Pet Care at Pharmacy2U
The UK's largest online pharmacy. Pet wormers, flea treatments, dental and joint care. Free delivery on orders over £30.
VetBox Flea & Worm Protection for Dogs
Vet-founded monthly parasite subscription. Flea, tick and worm protection delivered to your door. Founded by Dr Will Woodley, protecting 30,000+ pets.
We may earn a small commission if you purchase through these links, at no extra cost to you.