POM-V Prescription Required

Zuprevo 40mg/ml solution for injection for pigs

Active ingredient: Tildipirosin

Form

Injection

Species

Pigs

Manufacturer

Intervet International B.V.

VMD MA No.

EU/2/11/124/001-004

What it's used for

For the treatment and prevention of bovine respiratory disease (BRD) associated with Histophilus somni, Mannheimia haemolytica and The presence of the dise...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Tildipirosin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Zuprevo 40mg/ml solution for injection for pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For the treatment and prevention of bovine respiratory disease (BRD) associated
with Histophilus somni, Mannheimia haemolytica and
The presence of the disease in the group must be established before the product is used.

Do not use in cases of hypersensitivity to macrolide antibiotics or to any of
the excipients.
Do not administer simultaneously with other macrolides or lincosamides (see
section 4.8).

Cattle:
Very common
(>1 animal / 10 animals
treated):
Immediate pain upon injection, Injection site
swelling
, Injection site pain
, Injection site reaction
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylaxis
1
may be present up to 21 days post treatment
may be present up to 1 day post treatment
pathomorphological, will largely resolve within 35 days
may be fatal
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Revised: January 2024
AN: 03744/2022Page 3 of 6

There is cross resistance with other macrolides.

Special precautions for use in animals
Use of the product should be based on identification and susceptibility testing of
the target pathogen(s). If this is not possible, therapy should be based on
epidemiological information and knowledge of susceptibility of the target
pathogens at farm level, or at local/regional level.

Revised: January 2024
AN: 03744/2022Page 2 of 6
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
People with known hypersensitivity to tildipirosin should avoid contact with the
veterinary medicinal product.
Tildipirosin may cause sensitisation by skin contact. If accidental skin exposure occurs,
wash the skin immediately with soap and water. If accidental eye exposure occurs,
flush eyes immediately with clean water.
Wash hands after use.
Special caution should be taken to avoid accidental self-injection, as toxicology studies
in laboratory animals showed cardiovascular effects after intramuscular administration
of tildipirosin. In case of accidental self-injection, seek medical advice immediately and
show the package leaflet or the label to the physician.
Do not use in automatically powered syringes which have no additional protection system.
Special precautions for the protection of the environment:
Not applicable.
Other precautions
Not applicable.

The product should not be administered with antimicrobials with a similar mode of
action such as other macrolides or lincosamides. Please also refer to sections 4.3 and
4.4.

Do not store above 25 °C.

Revised: January 2024
AN: 03744/2022Page 6 of 6

Meat and offal: 47 days.
Not authorised for use in animals producing milk for human consumption.
Do not use in pregnant animals, which are intended to produce milk for human
consumption, within 2 months of expected parturition.

Revised: January 2024
AN: 03744/2022Page 4 of 6
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.