Zulvac BTV Suspension for Injection for Sheep and Cattle
Active ingredient: Bluetongue virus
Form
Injection
Species
Manufacturer
Zoetis UK Limited
VMD MA No.
42058/5091
What it's used for
Sheep: Active immunisation of sheep from 6 weeks of age for the prevention* of viraemia caused by bluetongue virus, serotype 1 or serotype 8. Active immuni...
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Zulvac BTV Suspension for Injection for Sheep and Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Active immunisation of sheep from 6 weeks of age for the prevention* of viraemia
caused by bluetongue virus, serotype 1 or serotype 8.
Active immunisation of sheep from 6 weeks of age for the reduction* of viraemia
caused by bluetongue virus, serotype 4.
*Below the level of detection of < 3.9 log10 genome copies/ml by the validated RT-
qPCR method, indicating no presence of viral genome.
Onset of immunity: 3 weeks after completion of the primary vaccination scheme.
Duration of immunity: 1 year after completion of the primary vaccination scheme.
Cattle:
Active immunisation of cattle from 12 weeks of age for the prevention** of viraemia
caused by bluetongue virus, serotype 1, serotype 4 or serotype 8.
**Below the level of detection of < 3.4 log10 genome copies/ml by a validated RT-
qPCR method, indicating no presence of viral genome.
Onset of immunity: Bluetongue virus, serotype 1: 15 days after completion of the
primary vaccination scheme.
Bluetongue virus, serotype 8: 25 days after completion of the
primary vaccination scheme.
Bluetongue virus, serotype 4: 14 days after completion of the
primary vaccination scheme.
Duration of immunity: Bluetongue virus, serotype 1: 1 year after completion of the
primary vaccination scheme.
Bluetongue virus, serotype 8: 1 year after completion of the
primary vaccination scheme.
Bluetongue virus, serotype 4: 6 months after completion of
the primary vaccination scheme.
There is evidence of BTV-1 seroneutralising antibodies indicative of protection for up
to 21 months after primary vaccination.
Revised September 2024
AN: 01966/2023
Very common
(>1 animal / 10 animals treated):
Elevated temperature
Injection site swelling
Injection site nodule
1
Transient, not exceeding 1.6 °C, observed during the 48 hours following vaccination.
Diffuse swelling, persisting for not more than 7 days.
Palpable granuloma, up to a size of 60 cm
, decreasing in size over time but
possibly persisting for more than 50 days.
Revised September 2024
AN: 01966/2023
Cattle administered a 2 ml dose:
Very common
(>1 animal / 10 animals
treated):
Injection site reaction
Common
(1 to 10 animals / 100 animals
treated):
Elevated temperature
1
Local reactions of up to 5 cm diameter were very commonly observed and reactions
> 5 cm diameter were commonly observed. These resolved within a maximum of 25
days.
Transient, not exceeding 2.7 °C, observed during the 48 hours following vaccination.
Cattle administered a 4 ml dose:
Very common
(>1 animal / 10 animals
treated):
Injection site reaction
Elevated temperature
1
Up to 6 cm in diameter, resolved in a maximum of 8 days.
Transient, not exceeding 2.7 °C, observed within the 48 hours following vaccination
with a maximum duration of 2 days.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also section 16 of the
package leaflet for contact details.
No information is available on the use of the vaccine in seropositive animals including
those with maternally derived antibodies.
If used in other domestic and wild ruminant species that are considered at risk of
infection, its use in these species should be undertaken with care and it is advisable
to test the vaccine on a small number of animals prior to mass vaccination. The level
of efficacy for other species may differ from that observed in sheep and cattle.
Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Not applicable.
Special precautions for the protection of the environment:
Not applicable.
Other precautions
Not applicable.
any other veterinary medicinal product. A decision to use this vaccine before or after
Revised September 2024
AN: 01966/2023
any other veterinary medicinal product therefore needs to be made on a case-by-
case basis.
Do not freeze.
Protect from light.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunologicals for Bovidae, inactivated viral
vaccines for cattle, bluetongue virus.
ATCvet code: QI02AA08
To stimulate active immunity of sheep and cattle against bluetongue virus serotype(s)
related to those contained in the vaccine.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Bluetongue virus
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Bluevac BTV Suspension for Injection for Cattle and Sheep
POM-VCZ Vaccines S.A.U.
Bluevac BTV Suspension for Injection for Cattle and Sheep
POM-VCZ Veterinaria S.A.
Bluevac-3 Suspension for Injection for Sheep and Cattle
POM-VCZ Veterinaria S.A.
BLUEVAC-3 Suspension for Injection for Sheep and Cattle
POM-VCZ Veterinaria S.A.
BTVPUR Suspension for Injection for Sheep and Cattle
POM-VBoehringer Ingelheim Vetmedica GmbH
BTVPUR Suspension for Injection for Sheep and Cattle
POM-VBoehringer Ingelheim Vetmedica Gmbh
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