POM-V Prescription Required

Vepured Suspension for Injection for Pigs

Active ingredient: Genetically modified recombinant Stx2e antigen

Form

Injection

Species

Pigs

Manufacturer

Laboratorios Hipra SA

VMD MA No.

17533/5012

What it's used for

Active immunisation of piglets from 2 days of age to prevent mortality and reduce clinical signs of oedema disease (caused by verotoxin 2e produced by E. c...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Vepured Suspension for Injection for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Active immunisation of piglets from 2 days of age to prevent mortality and reduce
clinical signs of oedema disease (caused by verotoxin 2e produced by E. coli) and to
reduce the loss of daily weight gain during the finishing period in the face of
infections with verotoxin 2e producing E. coli until slaughter from 164 days of age.
Onset of immunity: 21 days after vaccination.
Duration of immunity: 112 days after vaccination.

Intramuscular use.

Renewed Indefinitely: March 2022
AN: 02840/2021
Allow the vaccine to reach room temperature (15–25 ºC) before administration.
Shake well before use.
Administer a single intramuscular injection of 1 ml in the neck muscles.

Do not use in cases of hypersensitivity to the active substance, to the adjuvants or to
any of the excipients.

Very common adverse reactions:
- Mild inflammation at the injection site (< 5 cm in diameter) that typically
resolves within three days post-vaccination without treatment.
- Mild depression during the day of vaccination.
- Temperature rise of maximum 1.1 °C was observed. Temperatures returned to
normal within 24 hrs.
Emesis, recumbency, convulsion, lethargy and loss of consciousness occur in very
rare cases within a few minutes after vaccination. The animals mostly start to recover
within around 15 minutes. In case of severe anaphylactic-type reactions appropriate
treatment is recommended.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

Vaccinate healthy animals only.

Renewed Indefinitely: March 2022
AN: 02840/2021

Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by
case basis.

Store and transport refrigerated (2 ºC – 8 ºC).
Do not freeze.

Renewed Indefinitely: March 2022
AN: 02840/2021
Protect from light.

Zero days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunologicals for Suidae, inactivated bacterial
vaccines (including mycoplasma, toxoid and chlamydia).
ATC vet code: QI09AB02.
The vaccine consisting of recombinant verotoxin 2e stimulates an active immunity
against VT2e toxin produced by the causative agent of oedema disease in pigs.
Vaccinated animals are able to neutralise the VT2e toxin.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.