Varenzin 25 mg/ml Oral Suspension for Cats
Active ingredient: Molidustat Sodium
Form
Liquid
Species
Manufacturer
Elanco GmbH
VMD MA No.
52127/5065
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Paying less for Molidustat Sodium
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Prescription required
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Varenzin 25 mg/ml Oral Suspension for Cats — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
possible prior to starting treatment.
The veterinary medicinal product should be administered in accordance with the
following table to ensure a dose of 5.0 mg/kg, equivalent to 0.2 ml/kg:
Weight Range in
Kilograms (kg)
Volume (ml)20.42.1 to 2.50.52.6 to 3.00.63.1 to 3.50.73.6 to 4.00.84.1 to 4.50.94.6 to 5.01.05.1 to 5.51.15.6 to 6.01.2
For treating cats with a bodyweight greater than 6.0 kg, calculate the dose using 0.2
ml/kg bodyweight and round up to the nearest 0.1 ml.
Shake the bottle well before use and remove the screw cap. Place the syringe nozzle
firmly into the opening of the bottle. Turn the bottle upside down and withdraw the
required volume of the veterinary medicinal product into the syringe. Turn the bottle
back into an upright position before removing the syringe from the bottle. Administer
the contents of the syringe into the cat’s mouth. See illustrations 1 through to 4 below
for administration steps:
Step 1: Step 2:
Step 3: Step 4:
Amended pages: December 2025
After administration, close bottle tightly with cap and store syringe in the carton
together with the product. Do not disassemble or wash the syringe.
The veterinary medicinal product should be given once daily for up to 28 consecutive
days. If the cat vomits after consuming any portion of the dose, the cat should not be
re-dosed and should be considered as dosed for the day.
Monitoring and Repeated Treatment:
Treated cats should initially have their haematocrit (HCT) or packed cell volume
(PCV) levels monitored weekly beginning about the 14th day of the 28-day treatment
cycle to ensure HCT or PCV does not exceed the upper limit of the reference range.
Discontinue treatment if HCT or PCV exceeds the upper limit of the reference range.
After treatment cessation the haematocrit level should be periodically checked. When
the HCT or PCV level declines below the lower limit of the reference range, a new
treatment cycle should be started.
If a cat does not respond to treatment after 3 weeks, it is recommended to re-
examine the animal for any other underlying condition that may contribute to
anaemia, such as iron deficiency, inflammatory diseases or blood loss. It is advised
to treat the underlying condition before restarting treatment.
In a clinical field trial, 75 cats were evaluated for effectiveness (40 received Varenzin
and 35 received a control product), 68% of cats receiving Varenzin achieved
treatment success after 28 days of treatment, compared to 17% in the placebo
group. Treatment success was defined as an increase of ≥4% points in haematocrit
observed on Study Day 28 and/or an overall 25% increase in haematocrit from
baseline (Study Day 0).
excipients.
Common
(1 to 10 animals/ 100 animals treated):
Vomiting
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Amended pages: December 2025
Special precautions for safe use in the target species:
The safety of the veterinary medicinal product has not been evaluated in cats less
than 1 year of age or weighing less than 2 kg bodyweight.
Hypoxia-inducible factor (HIF) -prolyl hydroxylase (PH) inhibitors have been
associated with thromboembolic disease. Use with caution in cats that may be
predisposed to thromboembolic disease.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Accidental ingestion may cause flushing of the skin and/or orthostatic effects such as
dizziness. In case of accidental ingestion, seek medical advice immediately and
show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
erythropoiesis- stimulating agents, including recombinant erythropoietin drugs, has
not been studied.
Phosphate binders or other products containing multivalent cations such as calcium,
iron, magnesium or aluminium have been shown to chelate with other HIF-PH
inhibitors.
Amended pages: December 2025
Based on information in humans consider staggered administration of Varenzin and
phosphate binders or iron supplements (at least 1 hour apart), to prevent potentially
decreased absorption of molidustat. The veterinarian should consider monitoring
iron levels.
Do not store above 30°C.
Kilograms (kg)
Volume (ml)20.42.1 to 2.50.52.6 to 3.00.63.1 to 3.50.73.6 to 4.00.84.1 to 4.50.94.6 to 5.01.05.1 to 5.51.15.6 to
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Molidustat Sodium
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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