Tribex 100 mg/ml Oral Suspension for Cattle

Care should be taken to avoid the following practices, because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
• Under dosing, which may be due to under estimation of body weight,
misadministration of the product or lack of calibration of the dosing device (if any).

Amended pages: November 2025
AN: 01686/2025Page 2 of 6
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and having
a different mode of action should be used.
Resistance to triclabendazole has been reported in Fasciola hepatica in cattle.
Therefore, the use of this product should be based on local epidemiological
information about susceptibility of the Fasciola hepatica and recommendations on
how to limit further selection for resistance to anthelmintics.

Special precautions for use in animals
Only use for liver fluke strains susceptible to triclabendazole. Frequent and repeated
use may lead to the development of resistance. Care must be taken not to damage
the mouth or pharyngeal region when dosing. Clean drenching equipment before
and after use. Use unaltered product from the original container.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
When using the product do not eat, drink or smoke, Wear gloves. Wash splashes
from eyes and skin immediately. Take off any contaminated clothing immediately.
Wash hands and exposed skin before meals and after work. In cases of
hypersensitivity and contact allergy, direct skin contact and inhalation should be
avoided.
Other Precautions
The use of Tribex 10% may have harmful effects on fish and aquatic invertebrates.
Cattle must not have any access to surface water such as streams, ponds or ditches
within 7 days after treatment with Tribex. When spreading manure from treated
animals on arable lands a safety distance of 10 m to adjacent surface waters must
be kept.