POM-V Prescription Required

Tri-Solfen Cutaneous Solution for Pigs

Active ingredients: Bupivacaine, Cetrimide, Epinephrine, Lidocaine

Form

Solution

Species

Pigs

Manufacturer

Dechra Regulatory B.V.

VMD MA No.

50406/5033

What it's used for

Local anaesthesia during and following castration of piglets, and provision of castration wound antisepsis.

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Tri-Solfen Cutaneous Solution for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Local anaesthesia during and following castration of piglets, and provision of castration
wound antisepsis.

For cutaneous use only.
<2 kg bw = 1 ml per piglet
2-4 kg bw = 2 ml per piglet
Assemble the applicator as directed below. Set the dose at 0.5 ml. Incise the scrotum
and exteriorise the testis, exposing the spermatic cord. Instil 1 or 2 doses (depending on
the bodyweight) of 0.5 ml to the opened scrotal sac, to fully coat the spermatic cord and
the cut skin edge, then repeat for the other testicle. Wait 30 seconds before severing the
spermatic cords.
Use of Applicator:
Connect the long nozzle to the dosing applicator. Connect the dosing applicator and
draw-off tubing to the container as follows: Attach the tubing to the dosing applicator.
Attach draw-off tubing to the spigot cap. Remove the screw cap and seal, replace with
the spigot cap and draw-off tubing and check that they are firmly attached. Follow the
dosing applicator manufacturer's directions for priming the application and for proper use
and maintenance of the dosing applicator and draw-off tubing. The dosing applicator
should be removed at the end of each day’s use of the product. Remove the spigot cap
and replace with screw cap, checking it is firmly attached. When the dosing gun is

Revised: April 2025
AN: 04127/2024 & 03023/2024Page 4 of 6
removed, expel any remaining product in it and clean according to the manufacturer’s
directions, before storage.

Do not administer in cases of hypersensitivity to any of the active substances or to any
of the excipients.

Mild, transient (5-11 days duration) application site inflammation was the most commonly
reported adverse reaction in the clinical field trial. There was an isolated report of
anaphylaxis in one piglet.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

For use in piglets up to 7 days of age.

Revised: April 2025
AN: 04127/2024 & 03023/2024Page 2 of 6
The veterinary medicinal product will provide local anaesthesia within 30 seconds of
application, with a duration of effect of approximately 1 hour. Additional analgesia or
anaesthesia should be considered, according to recognised veterinary practice. No data
are available on concurrent use with other products (see also Section 4.8).

Special precautions for use in animals
In the clinical field trial, the product was not tested on piglets less than 3 days of age or
weighing less than 1 kg. Use only according to the benefit-risk assessment by the
responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Contact with skin or eyes can cause irritation and repetitive exposure can lead to allergic
reactions. Pharmacological effects (i.e. local anaesthesia) are likely to occur in case of
contact with the product.
Lidocaine and bupivacaine can form a metabolite (2,6-xylidine) in humans, which can
induce carcinogenic effects at high doses in long-term toxicology studies in rats.
Avoid skin, eye or oral contact with the product. Wear disposable impermeable gloves
when handling the product and treating animals.
In case of accidental spillage onto skin, wash off immediately with soap and water.
Avoid ingestion of and do not smoke or eat while handling the veterinary medicinal
product.
In case of accidental ingestion, seek medical advice and show the package insert to the
physician.
People with known hypersensitivity to any of the active substances or to any of the
excipients (e.g., sodium metabisulfite) should administer the product with caution.
Exposure to this product whilst using another medicinal product which also contains a
locally acting amide anaesthetic may cause cross sensitivity.
Wash hands thoroughly after use.

As no data are available on interactions, it is recommended not to apply other products to
the castration site when using this product.

Store below 30°C. Keep the container tightly closed in order to protect from light.

Revised: April 2025
AN: 04127/2024 & 03023/2024Page 6 of 6
Store the opened container below 25C.

Excipients:
Sodium metabisulfite 0.045 mg
Brilliant blue FCF (E133) 0.05 mg
For the full list of excipients, see section

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.