Tramvetol 50 mg Tablets for Dogs

The analgesic effects of tramadol hydrochloride may be variable. This is thought to
be due to individual differences in the metabolism of the drug to the primary active
metabolite O-desmethyltramadol. In some dogs (non-responders) this may result in
the product failing to provide analgesia. For chronic pain, multimodal analgesia
should be considered. Dogs should be monitored regularly by a veterinarian to
ensure adequate pain relief. In case of recurrence of pain or insufficient analgesia the
analgesic protocol may need to be reconsidered.

Special precautions for use in animals
Use with caution in dogs with renal or hepatic impairment. In dogs with hepatic
impairment the metabolism of tramadol to the active metabolites may be decreased
which may reduce the efficacy of the product. One of the active metabolites of
tramadol is renally excreted and therefore in dogs with renal impairment the dosing
regimen used may need to be adjusted. Renal and hepatic function should be
monitored when using this product. Cessation of long-term analgesic therapy should
be done gradually whenever possible.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Tramadol may cause sedation, nausea and dizziness after accidental ingestion,
especially by children. To avoid accidental ingestion, particularly by a child, unused
tablet parts should be returned to the open blister space and inserted back into the
carton and kept in a safe place out of the sight and reach of children.
In case of accidental ingestion, particularly by children, seek medical advice
immediately and show the package leaflet or the label to the physician. In case of
accidental ingestion by adults: DO NOT DRIVE as sedation may occur.
People with known hypersensitivity to tramadol or any of the excipients should avoid
contact with the veterinary medicinal product.
Wash hands after use.