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POM-V Prescription Required Companion Animal

Tramadog 50 mg Tablet for Dogs

Active ingredient: Tramadol Hydrochloride

Form

Tablet

Species

Dogs

Manufacturer

Axience

VMD MA No.

57179/5002

What it's used for

For the reduction of acute and chronic mild soft tissue and musculoskeletal pain.

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Tramadol Hydrochloride

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Tramadog 50 mg Tablet for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the reduction of acute and chronic mild soft tissue and musculoskeletal pain.
For oral use.
The recommended dose is 2-4 mg tramadol hydrochloride per kg body weight every 8
hours or as needed based on the intensity of pain.
Minimum dosing interval is 6 hours. The recommended maximum daily dose is 16
mg/kg. As the individual response to tramadol is variable and depends partly on the
dosage, the age of the animal, individual differences in pain sensitivity and general
condition, the optimal dosing regimen should be individually tailored using the above
dose and re-treatment interval ranges. The dog should be examined regularly by a
veterinarian to assess if additional analgesia is subsequently required. Additional
analgesia can be administered by increasing the tramadol dose until the maximum daily
dose is reached, and/or by following a multimodal analgesic approach with the addition
of other suitable analgesics.
Please note that this dosing table is intended as a guide for dispensing the product at
the high end of the dose range: 4 mg/kg bodyweight. It states the number of tablets
required to administer 4 mg tramadol hydrochloride per kg bodyweight.
Dog bodyweight
4 mg/kg dosage and no. of product tablets per
administration
3.12 kg 12.5 mg1/46.25 kg 25 mg1/29.37 kg 37.5 mg3/4

Revised: July 2025
AN: 01001/2025
Tablets can be divided into 2 or 4 equal parts to ensure accurate dosing. Place the
tablet on a flat surface, with its scored side facing up and the convex (rounded) side
facing the surface.
4 equal parts: press down with your thumb in the middle of the tablet.
2 equal parts: press down with your thumbs on both sides of the tablet.
Do not administer in conjunction with tricyclic antidepressants, monoamine oxidase
inhibitors and serotonin reuptake inhibitors.
Do not use in known cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with epilepsy.
Mild sedation and drowsiness may commonly occur, especially when higher doses are
given.
Nausea and vomiting have uncommonly been observed in dogs after administration of
tramadol.
In rare cases hypersensitivity can occur. In cases of hypersensitivity reactions the
treatment should be discontinued.
In very rare cases tramadol may induce convulsions in dogs with a low seizure
threshold.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
The analgesic effects of tramadol hydrochloride may be variable. This is thought to be
due to individual differences in the metabolism of the drug to the primary active
metabolite O-desmethyltramadol. In some dogs (non-responders) this may result in the
product failing to provide analgesia. For chronic pain, multimodal analgesia should be
considered. Dogs should be monitored regularly by a veterinarian to ensure adequate
pain relief. In case of recurrence of pain or insufficient analgesia the analgesic protocol
may need to be reconsidered.

Revised: July 2025
AN: 01001/2025

Special precautions for use in animals
As tablets are flavoured, store tablets out of reach of the animals in order to avoid
accidental ingestion.
The tablet can only be dosed correctly in dogs weighing more than 3.12 kg.
Use with caution in dogs with renal or hepatic impairment. In dogs with hepatic
impairment the metabolism of tramadol to the active metabolites may be decreased
which may reduce the efficacy of the product. One of the active metabolites of tramadol
is renally excreted and therefore in dogs with renal impairment the dosing regimen used
may need to be adjusted. Renal and hepatic function should be monitored when using
this product. Cessation of long-term analgesic therapy should be done gradually
whenever possible.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Tramadol may cause sedation, nausea and dizziness after accidental ingestion,
especially by children.
To avoid accidental ingestion, particularly by a child, unused tablet parts should be
returned to the open blister space and inserted back into the carton and kept in a safe
place out of the sight and reach of children.
In case of accidental ingestion, particularly by children, seek medical advice
immediately and show the package leaflet or the label to the physician. In case of
accidental ingestion by adults: do not drive as sedation may occur.
People with known hypersensitivity to tramadol or any of the excipients should avoid
contact with the veterinary medicinal product.
Wash hands after use.
Concomitant administration of this product with depressant drugs of the central nervous
system may potentiate the effects on C.N.S and respiratory depressant effects.
This product can increase the effect of drugs that lower the seizure threshold. Drugs
that inhibit (e.g. cimetidine and erythromycin) or induce (e.g. carbamazepine) CYP450
mediated metabolism may have an effect on the analgesic effect of this product. The
clinical relevance of this interaction has not yet been definitively studied.
The combination with mixed agonist/antagonists (e.g. buprenorphine, butorphanol) and
the product is not advisable, because the analgesic effect of a pure agonist may be
theoretically reduced in such circumstances.
See also section 4.3 Contraindications.
After piercing a blister, replace unused tablet parts into the blister and place the blister
back into the cardboard box.
This medicinal product does not require any special storage conditions.
Not applicable.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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