POM-V Prescription Required Companion Animal

Tolfedine 4% Solution for Injection for Use in Dogs and Cats

Active ingredient: Tolfenamic Acid

Form

Injection

Species

Cats Dogs

Manufacturer

Vetoquinol UK Limited

VMD MA No.

08007/5064

What it's used for

In dogs: inflammatory and painful post operative syndromes. In cats: adjuvant treatment of upper respiratory disease in association with antimicrobial ther...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Tolfenamic Acid

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Tolfedine 4% Solution for Injection for Use in Dogs and Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

In dogs: inflammatory and painful post operative syndromes.
In cats: adjuvant treatment of upper respiratory disease in association with
antimicrobial therapy

The recommended dose is 4 mg/kg bodyweight. That is a single injection of
1ml/10kg, repeated once after 24 hours if required (1ml/10kg) or a single injection of
1ml/10kg, the treatment being continued by the oral route, using tablets.
In dogs administer by intramuscular or subcutaneous injection. For the treatment of
post-operative pain, this is best given pre-operatively, either at the time of pre-
medication or induction of anaesthesia.
In cats by the subcutaneous route only.

Tolfenamic acid is contra-indicated in case of cardiac disease
Do not use in animals with impaired hepatic function or acute renal insufficiency
Tolfenamic acid is contra-indicated in case of ulceration or digestive bleeding, in case
of blood dyscrasia or hypersensitivity to tolfenamic acid.
Do not inject intramuscularly in cats.

Revised: December 2025
MA split from NI Expiry following AN: 03286/2025

A temporary increase in thirst and/or diuresis may occur. In most of the cases, these
signs cease spontaneously after treatment. Diarrhoea and vomiting may occur
during treatment, where either persists treatment should be discontinued.
Local injection site reactions have been reported following administration of this
product.

NSAIDS can cause inhibition of phagocytosis and hence in the treatment of
inflammatory conditions associated with bacterial infections appropriate concurrent
antimicrobial therapy should be instigated
The use of insulin-type needle/syringe is advisable particularly in low-weight animals
to ensure an accurate dose.

i. Special precautions for use in animals
Use in animals less than 6 weeks of age, or in aged animals, may involve additional
risk. If such a use cannot be avoided animals may require a reduced dosage and
careful clinical management is essential. Reduced metabolism and excretion in these
animals should be considered.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a
potential risk of increased renal toxicity.
Concurrent administration of potential nephrotoxic drugs should be avoided.
It is preferable that the product is not administered to cats undergoing general
anaesthesia until fully recovered.
Do not exceed the prescribed dosage or duration of treatment. The scale of pain
relief after pre-operative administration may be influenced by the severity and
duration of the operation.
Animals suffering from a chronic renal insufficiency and requiring an anti-
inflammatory treatment may be treated with tolfenamic acid without requiring an
adjustment of the dosage. However, the use of this product is contra-indicated in
acute cases of renal insufficiency.
In case of undesirable effects (anorexia, vomiting, diarrhoea, presence of blood in
faeces) occurring during the treatment, your veterinarian should be contacted for
advice and the possibility of stopping treatment should be considered.
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Take care to avoid accidental self-injection. In case of eye or skin contact, wash
immediately with water.

Revised: December 2025
MA split from NI Expiry following AN: 03286/2025

Do not administer other NSAIDs concurrently or within 24 hours of each other. Some
NSAIDs may be highly bound to plasma proteins and compete with other highly
bound drugs, which can lead to toxic effects.

Not applicable
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.