Synulox Palatable Tablets 400 mg/100 mg

Cross-resistance has been shown between amoxicillin/clavulanic acid and
other antibiotics belonging to the beta-lactam group. Use of the veterinary
medicinal product should be carefully considered when susceptibility testing
has shown resistance to other antimicrobials in the beta-lactam group because
its effectiveness may be reduced.
The veterinary medicinal product has no effect against infections caused by
Pseudomonas spp. due to its inherent resistance.

Special precautions for safe use in the target species:
Use of the product should be based on identification and susceptibility testing
of the target pathogen(s). If this is not possible, therapy should be based on
epidemiological information and knowledge of susceptibility of the target
pathogens at local/regional level.
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
An antibiotic with a lower risk of antimicrobial resistance selection (lower
AMEG category) should be used for first line treatment where susceptibility
testing suggests the likely efficacy of this approach.
Narrow spectrum antibiotic therapy with a lower risk of antimicrobial
resistance selection should be used for first line treatment where susceptibility
testing suggests the likely efficacy of this approach.
Pharmacokinetic of the active substances in the target tissue might be
considered as well.
The routine use of systemic antibiotics for intestinal infections is not
recommended.
Oral treatment with antibiotics can result in disturbance of gastrointestinal
flora, especially in case of long-term treatment.
In case of renal or hepatic insufficiency, the use of the veterinary medicinal
product should be subject to a benefit-risk assessment by the responsible
veterinarian.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion, or skin contact. Hypersensitivity to penicillins
can lead to cross-reactions with cephalosporins and vice versa. Allergic
reactions caused by these substances may occasionally be serious.
People with known hypersensitivity to the active substance should avoid
contact with the veterinary medicinal product. Wear gloves when handling this
product to avoid skin contact.
If you develop symptoms such as a skin rash and persistent eye irritation after
exposure to the veterinary medicinal product, seek medical advice
immediately and show the package leaflet or label to the physician. Swelling
of the face, lips, or eyes, or difficulty breathing are more serious symptoms
that require urgent medical attention.
Wash hands after use.
To prevent children from accessing the veterinary medicinal product, only the
required number of tablets should be removed from the blister pack and only
when required. Store any unused portion of the tablet in the opened blister
pack and return it into the carton immediately after use. The carton should be
stored out of the sight and reach of children. In case of accidental ingestion,
seek medical advice immediately and show the package leaflet or the label to
the physician.
Special precautions for the protection of the environment:
Not applicable.