POM-V Prescription Required Companion Animal

Synulox Palatable Drops 40 mg/ml + 10 mg/ml, Powder for Oral Suspension

Active ingredients: Amoxicillin, Clavulanic Acid

Form

Liquid

Species

Cats Dogs

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3091

What it's used for

- Soft tissue infections (including anal sacculitis and abscesses). - Urinary tract infections. - Respiratory infections. - Intestinal infections. - Period...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Amoxicillin + Clavulanic Aci...

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

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Clinical information

Synulox Palatable Drops 40 mg/ml + 10 mg/ml, Powder for Oral Suspension — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

- Soft tissue infections (including anal sacculitis and abscesses).
- Urinary tract infections.
- Respiratory infections.
- Intestinal infections.
- Periodontal infections in addition to mechanical or surgical periodontal therapy.
Cats:
For the treatment of
- Skin infections (including superficial pyoderma).
- Soft tissue infections (including abscesses).
- Urinary tract infections.
- Respiratory infections.
- Intestinal infections.
- Periodontal infections in addition to mechanical or surgical periodontal therapy.

Dosage: 10 mg amoxicillin and 2.5 mg clavulanic acid/kg body weight every 12 hours
equivalent to 0.25 ml reconstituted product/kg body weight every 12 hours or 5 drops
per kg body weight every 12 hours.
In refractory respiratory tract infections, the dose can be doubled to 20 mg amoxicillin
and 5 mg clavulanic acid/kg body weight every 12 hours and the treatment can be
prolonged for up to 10 days.
Dosing instructions:
Quantity (ml) of reconstituted veterinary medicinal
product every 12 hours per dose level
Body
weight
(kg)
10 mg amoxicillin and 2.5
mg clavulanic acid/kg
20 mg amoxicillin and 5 mg
clavulanic acid/kg
0.5 – 10.15 (3 drops*) to 0.25 (5
drops)
0.30 (6 drops) to 0.5 (10
drops)
>1 – 20.3 (6 drops) to 0.5 (10
drops)
0.6 (12 drops) to 1 (20 drops)>2 – 30.55 (11 drops) to 0.75 (15
drops)
1.1 (22 drops) to 1.5 (30
drops)
>3 – 40.8 (16 drops) to 1 (20
drops)
1.6 (32 drops) to 2 (40 drops)
*1 drop delivers approximately 0.05 ml of the suspension.
Duration of treatment:
In most of the cases, a treatment duration of 5 to 7 days is sufficient.
For chronic cases, a longer course of therapy may be required.
Based on clinical trials, the following treatment durations are recommended:
Chronic skin infections, 10–20 days.
Chronic cystitis, 10–28 days.
Instructions for use:
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Open the bottle. Discard the original aluminium cap. Reconstitute the powder with 15 ml
of tap water. Close the bottle with the dropper cap and shake vigorously to obtain a
milky suspension. Open the bottle and use the dropper (graduated from 0.25 to 1 ml) to
extract the prescribed amount. If needed, gently squeeze the rubber portion of the
dropper to drop the excess of the veterinary medicinal product back into the bottle.
Administer the veterinary medicinal product with the graduated dropper either directly
into the animal’s mouth or mixed with some food.
Shake the veterinary medicinal product well before each use.

Do not use in rabbits, guinea pigs, hamsters, gerbils, chinchillas or other small
herbivores.
Do not use in cases of hypersensitivity to the active substances, other substances of the
beta-lactam group or to any of the excipients.
Do not administer to horses or ruminating animals.
Do not use in animals with severe renal impairment with anuria or oliguria.

Dogs and cats:
Common
(1 to 10 animals / 100 animals
treated):
gastrointestinal disorder
(e.g. vomiting,
diarrhoea)
Uncommon
(1 to 10 animals / 1 000 animals
treated):
hypersalivation
anorexia
1, 2
, lethargy

Very rare
(<1 animal / 10 000 animals
treated, including isolated reports):
hypersensitivity reaction
(e.g. allergic skin
reaction, anaphylaxis)
Depending on the severity of the adverse event treatment should be discontinued and
symptomatic treatment initiated based on the benefit-risk assessment by the
responsible veterinarian.
Very rare (<1 animal / 10 000 animals treated, including isolated reports) in cats.
May be serious. Immediate discontinuation of the veterinary medicinal product is
required. Countermeasures to be taken in case of an allergic reaction:
-
-
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Cross-resistance has been shown between amoxicillin/clavulanic acid and other
antibiotics belonging to the beta-lactam group. Use of the veterinary medicinal product
should be carefully considered when susceptibility testing has shown resistance to other
antimicrobials in the beta-lactam group because its effectiveness may be reduced.
The veterinary medicinal product has no effect against infections caused by
Pseudomonas spp. due to its inherent resistance.

Special precautions for safe use in the target species:
Use of the product should be based on identification and susceptibility testing of the
target pathogen(s). If this is not possible, therapy should be based on epidemiological
information and knowledge of susceptibility of the target pathogens at local/regional
level.
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
An antibiotic with a lower risk of antimicrobial resistance selection (lower AMEG
category) should be used for first line treatment where susceptibility testing suggests
the likely efficacy of this approach.
Narrow spectrum antibiotic therapy with a lower risk of antimicrobial resistance selection
should be used for first line treatment where susceptibility testing suggests the likely
efficacy of this approach.
Pharmacokinetic of the active substances in the target tissue might be considered as
well.
The routine use of systemic antibiotics for intestinal infections is not recommended.
Oral treatment with antibiotics can result in disturbance of gastrointestinal flora,
especially in case of long-term treatment.
In case of renal or hepatic insufficiency, the use of the veterinary medicinal product
should be subject to a benefit-risk assessment by the responsible veterinarian.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion, or skin contact. Hypersensitivity to penicillins can lead to cross-
reactions with cephalosporins and vice versa. Allergic reactions caused by these
substances may occasionally be serious.
People with known hypersensitivity to the active substance should avoid contact with
the veterinary medicinal product. Wear gloves when handling this product to avoid skin
contact.
In case of accidental spillage onto skin or eyes immediately wash the affected area with
plenty of water.
If you develop symptoms such as a skin rash and persistent eye irritation after exposure
to the veterinary medicinal product, seek medical advice immediately and show the
package leaflet or label to the physician. Swelling of the face, lips, or eyes, or difficulty
breathing are more serious symptoms that require urgent medical attention.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

The bactericidal effect of amoxicillin may be inhibited by the concomitant use of
bacteriostatic antimicrobials.
Penicillins may increase the effect of aminoglycosides.

Do not store above 25°C.
Store the reconstituted veterinary medicinal product in a refrigerator (2°C - 8°C).

Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.