POM-V Prescription Required

Synulox Lactating Cow Intramammary Suspension

Active ingredients: Amoxicillin, Clavulanic Acid, Prednisolone

Form

Intramammary

Species

Cattle

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5105

What it's used for

For use in clinical cases of mastitis including cases associated with infections with the following pathogens: Staphylococci (including -lactamase produci...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Synulox Lactating Cow Intramammary Suspension — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For use in clinical cases of mastitis including cases associated with infections with
the following pathogens:
Staphylococci (including -lactamase producing strains)
Streptococci (including , S. dysgalactiaeS. uberis)
Escherichia coli (including -lactamase producing strains)

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals which are known to be hypersensitive to -lactamase
antibiotics.

Revised: March 2026
AN: 04408/2025

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See also section 16 of the
package leaflet for respective contact details.

Do not use in cases associated with

i) Special precautions for use in animals
Swab teat end with appropriate disinfectant before treatment.
Recommendations for prudent use
The product should be used for treatment of clinical mastitis only.
Use of the product should be based on local (regional, farm level) epidemiological
information about susceptibility of the target bacteria and take into account official
and local antimicrobial policies.
The use of the product should preferably be based on susceptibility tests.
Avoid use of the product in herds where no β-lactamase
strains have been isolated. Veterinarians should strive to use narrow spectrum
antibiotics if possible. Inappropriate use of the product may increase the prevalence
of bacteria resistant to ß-lactam antibiotics and may decrease the effectiveness of
treatment with ß-lactam antibiotics, due to the potential for cross-resistance.
ii) Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead
to cross reactions to cephalosporins and vice versa. Allergic reactions to these
substances may occasionally be serious.
Do not handle this product if you know you are sensitised, or if you have been
advised not to work with such preparations.
Handle this product with great care to avoid exposure, taking all recommended
precautions.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes or
difficulty with breathing, are more serious symptoms and require urgent medical
attention.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

Revised: March 2026
AN: 04408/2025

None known.

Do not store above 25°C.
Store in a dry place.

Revised: March 2026
AN: 04408/2025

Meat and offal: 7 days.
Milk: 84 hours.
With cows milked twice daily, milk for human consumption may only be taken from
the 7th milking after the last treatment. Where any other milking routine is followed,
milk may be taken for human consumption only after the same period from the last
treatment (e.g. with 3 times a day milking, milk may be taken for human consumption
at the 11th milking).
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.