POM-V Prescription Required Companion Animal

Synuclav 40 mg/10 mg Tablets for Dogs and Cats

Active ingredients: Amoxicillin, Clavulanic Acid

Form

Tablet

Species

Cats Dogs

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/3003

What it's used for

•Escherichia coli. • •Escherichia coli. It is recommended to carry out suitable tests for sensitivity testing when initiating the treatment. The treatment...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Synuclav 40 mg/10 mg Tablets for Dogs and Cats — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

•Escherichia coli.
•
•Escherichia coli.
It is recommended to carry out suitable tests for sensitivity testing when initiating the
treatment. The treatment should only proceed if sensitivity is proven to the combination.

tablets may be crushed and added to a little food.
The following table is intended as a guide to dispensing the product at the standard dose
rate of 12.5 mg of combined actives per kg twice daily.
BodyweightNumber of tablets twice daily1-20.53-415-61.57-829-102.511-12313-143.515-16417-184.5
Duration of therapy
Acute cases: 5 to 7 days of treatment.
If no improvement is observed after 5 to 7 days, the diagnosis should be re-assessed.
Chronic or refractory cases: In these cases where there is considerable tissue damage, a
longer course of therapy may be required so that it allows sufficient time for damaged
tissue to repair.
If no improvement is observed after two weeks, the diagnosis should be re-assessed.

Do not use in cases of hypersensitivity to penicillin, other substances of the beta-lactam
group or to any of the excipients.
Do not use in rabbits, guinea pigs, hamsters or gerbils.
Do not use in animals with serious dysfunction of the kidneys accompanied by anuria and
oliguria.
Do not use where resistance to this combination is known to occur.
Do not administer to horses and ruminating animals.

Dogs and cats:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Gastrointestinal disorders (Diarrhoea,
Vomiting)
Allergic reactions (e.g. skin reaction,
anaphylaxis)
Hypersensitivity reactions
1
In these cases, treatment should be withdrawn.
Unrelated to dose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

None.

Special precautions for safe use in the target species:
Inappropriate use of the product may increase the prevalence of bacteria resistant to
amoxicillin/clavulanic acid.
In animals with hepatic and renal failure, the dosing regimen should be carefully evaluated.
Use of the product should be based on susceptibility testing and take into account official
and local antimicrobial policies. Narrow spectrum antibacterial therapy should be used for
first line treatment where susceptibility testing suggests likely efficacy of this approach.
Caution is advised in the use in small herbivores other than those in 3.3.
Dogs and cats diagnosed with Pseudomonas infections should not be treated with this
antibiotic combination.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion, or skin contact. Hypersensitivity to penicillins may lead to cross-
reactions to cephalosporins and vice versa. Allergic reactions to these substances may
occasionally be serious.
Do not handle this veterinary medicinal product if you know you are sensitised, or if you
have been advised not to work with such preparations.
Handle this veterinary medicinal product with great care to avoid exposure, taking all
recommended precautions.
If you develop symptoms following exposure such as a skin rash, you should seek medical
advice and show the package leaflet or the label to the physician. Swelling of the face, lips
or eyes or difficulty with breathing are more serious symptoms and require urgent medical
attention.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

Chloramphenicol, macrolides, sulfonamides and tetracyclines may inhibit the antibacterial
effect of penicillins because of the rapid onset of bacteriostatic action. The potential for
allergic cross-reactivity with other penicillins should be considered. Penicillins may
increase the effect of aminoglycosides.

Do not store above 25 C.
Store in the original package in order to protect from moisture.

Not applicable.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.