Synuclav 200 mg/50 mg Tablets for Dogs
Active ingredients: Amoxicillin, Clavulanic Acid
Form
Tablet
Species
Manufacturer
Norbrook Laboratories Limited
VMD MA No.
02000/5014
What it's used for
•Escherichia coli. • • It is recommended to carry out suitable tests for sensitivity testing when initiating the treatment. The treatment should only proce...
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Prescription required
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Synuclav 200 mg/50 mg Tablets for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
•
•
It is recommended to carry out suitable tests for sensitivity testing when initiating the
treatment. The treatment should only proceed if sensitivity is proven to the
combination.
The following table is intended as a guide to dispensing the product at the standard
dose rate of 12.5 mg of combined actives per kg twice daily.
AN: 00657/2025 & 00662/2025
BodyweightNumber of tablets twice
daily
19-20121-301.531-40241-502.5More than 503
Duration of therapy
Acute cases: 5 to 7 days of treatment.
If no improvement is observed after 5 to 7 days, the diagnosis should be re-assessed.
Chronic or refractory cases: In these cases where there is considerable tissue
damage, a longer course of therapy may be required so that it allows sufficient time for
damaged tissue to repair.
If no improvement is observed after two weeks, the diagnosis should be re-assessed.
lactam group or to any of the excipients.
Do not use in rabbits, guinea pigs, hamsters or gerbils.
Do not use in animals with serious dysfunction of the kidneys accompanied by anuria
and oliguria.
Do not use where resistance to this combination is known to occur.
Do not administer to horses and ruminating animals.
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Gastrointestinal disorders (Diarrhoea, Vomiting)
Allergic reactions (e.g. skin reaction, anaphylaxis)
Hypersensitivity reactions
1
In these cases, treatment should be withdrawn.
Unrelated to dose.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Special precautions for safe use in the target species:
Inappropriate use of the product may increase the prevalence of bacteria resistant to
amoxicillin/clavulanic acid.
In animals with hepatic and renal failure, the dosing regimen should be carefully
evaluated.
Use of the product should be based on susceptibility testing and take into account
official and local antimicrobial policies. Narrow spectrum antibacterial therapy should
be used for first line treatment where susceptibility testing suggests likely efficacy of
this approach.
Caution is advised in the use in small herbivores other than those in 3.3.
Dogs and cats diagnosed with Pseudomonas infections should not be treated with this
antibiotic combination.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion, or skin contact. Hypersensitivity to penicillins may lead to cross-
reactions to cephalosporins and vice versa. Allergic reactions to these substances
may occasionally be serious.
Do not handle this veterinary medicinal product if you know you are sensitised, or if
you have been advised not to work with such preparations.
AN: 00657/2025 & 00662/2025
Handle this veterinary medicinal product with great care to avoid exposure, taking all
recommended precautions.
If you develop symptoms following exposure such as a skin rash, you should seek
medical advice and show the package leaflet or the label to the physician. Swelling of
the face, lips or eyes or difficulty with breathing are more serious symptoms and
require urgent medical attention.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
antibacterial effect of penicillins because of the rapid onset of bacteriostatic action.
The potential for allergic cross-reactivity with other penicillins should be considered.
Penicillins may increase the effect of aminoglycosides.
AN: 00657/2025 & 00662/2025
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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