POM-V Prescription Required

Suiseng Diff/A Suspension for Injection for Pigs

Active ingredients: Clostridioides difficile, Clostridium perfringens

Form

Injection

Species

Pigs

Manufacturer

Laboratorios Hipra SA

VMD MA No.

17533/5013

What it's used for

For the passive immunisation of neonatal piglets by means of the active immunisation of breeding sows and gilts: - C. difficile, toxins A and B. - type A,...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Suiseng Diff/A Suspension for Injection for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the passive immunisation of neonatal piglets by means of the active
immunisation of breeding sows and gilts:
-
C. difficile, toxins A and B.
- type A,
α-toxin.
The reduction of the occurrence of neonatal diarrhoea has been demonstrated under
field conditions.
Onset of immunity:
Protection was demonstrated in suckling piglets on the first day of life in challenge
studies.
Duration of immunity:

Revised: July 2024
AN: 02734/2023
Neutralising protective antibodies transferred via colostrum to the piglets were
present up to 28 days after birth in the majority of the piglets.

Administer the vaccine by deep intramuscular injection in the neck muscles.
Allow the vaccine to reach room temperature (15°C to 25 °C) before use.
Shake well before use.
Primary vaccination:
Administer one dose (2 ml) at approximately 6 weeks before farrowing and a second
dose (2 ml) at approximately 3 weeks before farrowing.
It is recommended that the second dose is given preferably on alternate sides.
Revaccination:
On each subsequent gestation, administer one dose (2ml) 3 weeks before the
expected date of farrowing.
To ensure the correct mixing with Suiseng Coli/C, the same volumes of Suiseng Diff/A
and Suiseng Coli/C should be used. All the contents of Suiseng Coli/C should be
transferred into a headspace bottle of Suiseng Diff/A (50 ml bottle with 10 doses, 100
ml bottle with 25 doses and 250 ml bottle with 50 doses).
A pre-sterilised transfer needle can be used according to the following instructions:
-
-
-
-
-
-
Shake well before use. Administer one single dose of 4 ml of the mixed vaccines.

Do not use in cases of hypersensitivity to the active substance, to the adjuvant or to
any of the excipients.

Mild local inflammation at the injection site (maximum diameter of 5 cm) which
subsided without treatment within 5 days was commonly reported in laboratory
studies.
A slight transient increase in body temperature (mean 0.27ºC, in individual pigs up to
0.95 ºC) which subsided without treatment occurred commonly in preclinical and field
studies.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reactions)
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).

Vaccinate healthy animals only.
Protection of piglets is achieved by colostrum intake. Therefore, care should be taken
to ensure that each piglet ingests a sufficient quantity of colostrum within the first
hours of life.

Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
None.

Safety and efficacy data are available which demonstrate that this vaccine can be
mixed and administered at one injection site with Suiseng Coli/C. Following
administration of the mixed vaccines, an increase in body temperature (mean 1.43°C,
not exceeding 1.87 ºC in individual pigs) during the first 6 hours after vaccination

Revised: July 2024
AN: 02734/2023
occurs very commonly. Injection site swelling (maximum 4 cm) occurs very commonly,
but typically will resolve within 4 days.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product except the product mentioned above. A
decision to use this vaccine before or after any other veterinary medicinal product
therefore needs to be made on a case by case basis

Zero days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunologicals for Suidae, inactivated bacterial
vaccines for pigs, clostridium.
ATCvet code: QI09AB12.
The active immunisation of pregnant sows and gilts induces the production of
neutralising antibodies against type A,

Revised: July 2024
AN: 02734/2023
toxin. These antibodies are transferred via the colostrum to the piglets. The uptake of
sufficient colostrum within the first hours of life results in a passive protection of piglets.
Efficacy of the vaccine was demonstrated upon intraperitoneal challenge with
difficile type A. The efficacy of the
vaccine to reduce the occurrence of diarrhoea was demonstrated under field
conditions.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.