POM-V Prescription Required

Rispoval RS+PI3 Intranasal Nasal Spray Lyophilisate and Solvent for Suspension for Cattle

Active ingredients: Bovine parainfluenza virus 3, Bovine respiratory syncytial virus

Form

Injection

Species

Cattle

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3052

What it's used for

Onset of immunity: 5 days for BRSV and 10 days for PI3V after a single vaccination. Duration of immunity: 12 weeks after a single vaccination.The duration...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Rispoval RS+PI3 Intranasal Nasal Spray Lyophilisate and Solvent for Suspension for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: 5 days for BRSV and 10 days for PI3V after a single vaccination.
Duration of immunity: 12 weeks after a single vaccination.The duration of protective
immunity against the PI3V fraction may be reduced in MDA positive calves vaccinated
before 3 weeks of age.
For primary vaccination using Rispoval RS/Pi3 IntraNasal and booster vaccination with
Rispoval 2/BRSV + Pi3*, refer to the Rispoval 2/BRSV Pi3* product information for
specific details on indications.
* Where this veterinary medicinal product is authorised.

Route: nasal use.
Reconstitution of the vaccine:
Reconstitute the 1 dose and 5 dose presentations by aseptically adding the solvent to
the vial containing the lyophilisate. Shake well before use.
Reconstitute the 25 dose presentation by mixing the lyophilised fraction with the
solvent in 2 steps:
1. Inject 10 ml of the solvent on the lyophilised plug in the vial containing the
lyophilisate.
2. Shake well and extract the reconstituted lyophilised fraction from the vial and
mix with the remaining solvent in the liquid fraction vial.
Shake well before use.
Reconstituted product: pink to orange liquid, which might contain a loose
resuspendable sediment.
Vaccination programme:
Basic vaccination: A single dose of 2 ml of reconstituted vaccine should be given using
the intranasal applicator available from Zoetis to cattle from the age of 9 days.
It is recommended to change applicators between animals to avoid transmitting
infectious organisms.
For primary vaccination using Rispoval RS/Pi3 IntraNasal and booster vaccination with
Rispoval 2/BRSV + Pi3*, refer to the Rispoval 2/BRSV Pi3* product information for
specific details on vaccination programme.
* Where this veterinary medicinal product is authorised.

None.

Cattle:
Rare
(1 to 10 animals / 10,000 animals
treated):
Hypersensitivity reaction(e.g. anaphylactic-type
reaction)
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Vaccinate healthy animals only.
Animals should preferably be vaccinated at least 10 days before a period of stress or
high infection risk like re-grouping or transport of animals, or at the start of the autumn
season. To achieve optimal results, it is recommended to vaccinate all the calves
within the same herd.

Special precautions for safe use in the target species:
Vaccinal viruses can spread from vaccinated to non-vaccinated calves and may cause
a serological response, but without causing clinical signs. In laboratory experiments
based on the data using 3 week-old animals, shedding was observed for BRSV and
PI3V up to 11 and 7 days respectively after vaccination with one dose containing the
maximal virus content.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Not applicable.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product. A decision to use this vaccine before or after any
other veterinary medicinal product therefore needs to be made on a case by case basis.

Store and transport refrigerated (2 °C - 8 °C).
Do not freeze.
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.