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Rispoval 3 BRSV Pi3 BVD Lyophilisate and Suspension for Suspension for Injection for Cattle

Active ingredients: Bovine parainfluenza virus 3, Bovine respiratory syncytial virus, Bovine viral diarrhoea virus

Form

Injection

Species

Cattle

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3044

What it's used for

Onset of immunity: 3 weeks. Duration of immunity:6 months (demonstrated by challenge studies) for BRSV and BVDV Type 1. Duration of immunity has not been e...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Rispoval 3 BRSV Pi3 BVD Lyophilisate and Suspension for Suspension for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: 3 weeks.
Duration of immunity:6 months (demonstrated by challenge studies) for BRSV and BVDV
Type 1. Duration of immunity has not been established for bovine Pi3
virus.
Efficacy has not been demonstrated against BVDV Type 2 strains.

Route: intramuscular.
Reconstitution of the vaccine:
Reconstitute the vaccine by adding the suspension to the vial containing the lyophilisate.
When the lyophilisate and suspension are filled in equally sized vials, inject the entire
suspension into the vial containing the lyophilisate.
When the lyophilisate is filled in a smaller vial size than the suspension, the reconstitution
of the vaccine is carried out in 2 steps:
1. Inject 10 ml of the suspension on the lyophilised plug in the vial containing the
lyophilisate.
2. Shake well and extract the reconstituted lyophilised fraction from the vial and mix
with the remaining suspension in the liquid fraction vial.
Shake well before use.
Reconstituted product is a slightly coloured turbid liquid which might contain a loose
sediment which is easily resuspended on shaking well.
Vaccination scheme:
Administer one dose (4 ml) of the reconstituted vaccine according to the following
vaccination scheme:
Basic immunisation: two doses, each of 4 ml, 3-4 weeks apart from 12 weeks of
age.
Booster vaccinations: if protection against BRSV and BVDV Type 1 is required, then
animals should be revaccinated after 6 months.
Animals should be preferably vaccinated at least 3 weeks before a period of stress or high
infection risk like re-grouping or transport of animals, or the start of autumn season. The
duration of immunity of the Pi3 component is not known.

None.

Cattle:
Very common
(>1 animal / 10 animals treated):
Hyperthermia
Injection site inflammation
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypersensitivity reaction, anaphylactic-type
reaction
Transient and mild; can last for 2 days.
Transient and minor; up to 0.5 cm which disappears within 15 days.
In case of anaphylactic reaction, symptomatic treatment should be provided.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the package
leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product. A decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be made on a case by case basis.

Store and transport refrigerated (2 °C – 8 °C).
Do not freeze.
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.