POM-V Prescription Required

Rispoval 2 / BRSV + Pi3 Lyophilisate and Solvent for Suspension for Injection for Cattle

Active ingredients: Bovine parainfluenza virus 3, Bovine respiratory syncytial virus

Form

Injection

Species

Cattle

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3051

What it's used for

Duration of immunity: 6 months after the basic vaccination scheme for BRSV. Duration of immunity has not been established for bovine Pi3V. For active immun...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Rispoval 2 / BRSV + Pi3 Lyophilisate and Solvent for Suspension for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Duration of immunity: 6 months after the basic vaccination scheme for BRSV. Duration of
immunity has not been established for bovine Pi3V.
For active immunisation with Rispoval RS+Pi3 IntraNasal* as basic vaccination and
Rispoval 2 as booster vaccination from 13 weeks of age to:
- reduce virus excretion caused by bovine Pi3V and BRSV infection and
- reduce clinical signs (cough, depression, dyspnea, increased respiratory rate,
elevated rectal temperature) associated with BRSV infection.
Onset of immunity: 3 weeks after the booster vaccination.
Duration of immunity: 6 months for BRSV and 3 months for Pi3V after the booster
vaccination.
* Where this veterinary medicinal product is authorised.

Route: intramuscular use.
Reconstitution of the vaccine:
Reconstitute the vaccine by adding the solvent to the vial containing the lyophilisate.
When the lyophilisate and solvent are filled in equally sized vials, inject the entire solvent
into the vial containing the lyophilisate.
When the lyophilisate is filled in a smaller vial size than the solvent, the reconstitution of
the vaccine is carried out in 2 steps:
1. Inject 10 ml of the solvent on the lyophilised plug in the vial containing the
lyophilisate.
2. Shake well and extract the reconstituted lyophilised fraction from the vial and mix
with the remaining solvent in the liquid fraction vial.
Shake well before use.
Reconstituted product: pink-orange turbid suspension with loose sediment.
Vaccination scheme:
For vaccination with Rispoval 2 only:
Basic vaccination: two doses 3-4 weeks apart from 12 weeks of age.
Re-vaccination: if continued protection against BRSV is required, then animals should be
revaccinated after 6 months. The duration of immunity of the Pi3V component is not
known.
For use as a booster vaccination after basic vaccination with Rispoval RS+Pi3 IntraNasal*:
A single dose of Rispoval 2 three months after the basic vaccination with Rispoval RS+Pi3
IntraNasal*.
If continued protection against BRSV is required, then animals should be revaccinated with
a single dose after 6 months. If continued protection against Pi3V is required, then animals
should be revaccinated with a single dose after 3 months.
* Where this veterinary medicinal product is authorised.
Animals should preferably be vaccinated at least 3 weeks before a period of stress or high
infection risk such as re-grouping or transport of animals, or the start of autumn season.

None.

Cattle:
Very common
(>1 animal / 10 animals treated):
Hyperthermia
Injection site inflammation
Very rare
(<1 animal / 10,000 animals
treated, including isolated reports):
Hypersensitivity reaction (e.g. anaphylactic-type
reaction)
1
Transient and mild; can last for 2 days.
Transient and minor; up to 0.5 cm which disappears within 15 days.
In case of anaphylactic reaction, symptomatic treatment should be provided.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Vaccinate healthy animals only.

Special precautions for safe use in the target species:
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the package
leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product. A decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be made on a case by case basis.

Store and transport refrigerated (2 °C – 8 °C).
Do not freeze.
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.