POM-V Prescription Required

Rexxolide 100 mg/ml Solution for Injection for Cattle, Pigs and Sheep

Active ingredient: Tulathromycin

Form

Injection

Species

Cattle Pigs Sheep

Manufacturer

Dechra Regulatory B.V.

VMD MA No.

50406/5052

What it's used for

Treatment of infectious bovine keratoconjunctivitis (IBK) associated with bovis Pigs: Treatment and metaphylaxis of swine respiratory disease (SRD) associa...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Tulathromycin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Rexxolide 100 mg/ml Solution for Injection for Cattle, Pigs and Sheep — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Treatment of infectious bovine keratoconjunctivitis (IBK) associated with
bovis
Pigs:
Treatment and metaphylaxis of swine respiratory disease (SRD) associated with
Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma
hyopneumoniae, Haemophilus parasuis and susceptible to
tulathromycin. The presence of the disease in the group must be established before
the veterinary medicinal product is used. The veterinary medicinal product should
only be used if pigs are expected to develop the disease within 2–3 days.
Sheep:
Treatment of the early stages of infectious pododermatitis (foot rot) associated with
virulent Dichelobacter nodosus requiring systemic treatment.

A single subcutaneous injection of 2.5 mg tulathromycin/kg bodyweight (equivalent to
1 ml/40 kg bodyweight). For treatment of cattle over 300 kg bodyweight, divide the
dose so that no more than 7.5 ml are injected at one site.
Pigs:
Intramuscular use.
A single intramuscular injection of 2.5 mg tulathromycin/kg bodyweight (equivalent to
1 ml/40 kg bodyweight) in the neck.
For treatment of pigs over 80 kg bodyweight, divide the dose so that no more than 2 ml
are injected at one site.
For any respiratory disease, it is recommended to treat animals in the early stages of
the disease and to evaluate the response to treatment within 48 hours after injection.
If clinical signs of respiratory disease persist or increase, or if relapse occurs,
treatment should be changed, using another antibiotic, and continued until clinical
signs have resolved.
Sheep:
Intramuscular use.
A single intramuscular injection of 2.5 mg tulathromycin/kg body weight (equivalent to
1 ml/40 kg body weight) in the neck.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
For multiple vial entry, an aspirating needle or multi-dose syringe is recommended to
avoid excessive broaching of the stopper. The stopper may be safely punctured up to
25 times.

Do not use in cases of hypersensitivity to macrolide antibiotics or to any of the
excipients.

Cattle:
Very common
(>1 animal / 10 animals
treated):
Injection site pain
a
, injection site swelling
a
Injection site reactions (e.g. injection site
congestion, injection site oedema, injection site
fibrosis, injection site haemorrhage)
b

a
Transient, can persist for up to 30 days.
b
Pathomorphological reversible changes, for approximately 30 days after injection.
Pigs:
Very common
(>1 animal / 10 animals
treated):
Injection site reactions (e.g. injection site
congestion, injection site oedema, injection site
fibrosis, injection site haemorrhage)
a
a
Pathomorphological reversible changes, for approximately 30 days after injection.
Sheep:
Very common
(>1 animal / 10 animals
treated):
Discomfort
a
Head shake
a
, backing away
a
Injection site scratching
a
a
These signs resolve within a few minutes.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also the package leaflet
for respective contact details.

Cross resistance occurs with other macrolides. Do not administer simultaneously with
antimicrobials with a similar mode of action such as other macrolides or
lincosamides.
Sheep:
The efficacy of antimicrobial treatment of foot rot might be reduced by other factors,
such as wet environmental conditions, as well as inappropriate farm management.
Treatment of foot rot should therefore be undertaken along with other flock
management tools, for example providing dry environment.
Antibiotic treatment of benign foot rot is not considered appropriate. Tulathromycin
showed limited efficacy in sheep with severe clinical signs or chronic foot rot, and
should therefore only be given at an early stage of foot rot.

Special precautions for safe use in the target species:
Use of the product should be based on identification and susceptibility testing of the
target pathogen(s). If this is not possible, therapy should be based on
epidemiological information and knowledge of susceptibility of the target pathogens
at farm level, or at local/regional level.
Use of the product should be in accordance with official, national and regional
antimicrobial policies.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to tulathromycin and may
decrease the effectiveness of treatment with other macrolides, lincosamides and
group B streptogramins, due to the potential for cross resistance.
If a hypersensitivity reaction occurs, appropriate treatment should be administered
without delay.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Tulathromycin is irritating to eyes. In case of accidental eye exposure, flush the eyes
immediately with clean water.
Tulathromycin may cause sensitisation by skin contact resulting in e.g. reddening of
the skin (erythema) and/or dermatitis. In case of accidental spillage onto skin, wash
the skin immediately with soap and water.
Wash hands after use.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
If there is suspicion of a hypersensitivity reaction following accidental exposure
(recognised by e.g. itching, difficulty in breathing, hives, swelling on the face, nausea,
vomiting) appropriate treatment should be administered. Seek medical advice
immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

None known.

This veterinary medicinal product does not require any special storage conditions.

Cattle (meat and offal): 22 days
Pigs (meat and offal): 13 days
Sheep (meat and offal): 16 days
Not authorised for use in animals producing milk for human consumption.
Do not use in pregnant animals which are intended to produce milk for human
consumption within 2 months of expected parturition.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.