Prosolvin 7.5 mg/ml Solution for Injection

Oestrus control: cows and heifers treated during the luteal phase will normally
return to oestrus and ovulate 2-4 days after treatment. In mares oestrus will
normally occur within 5 days of treatment followed by ovulation 2-4 days later.
Oestrus synchronisation: when a group of cows at different stages in the
oestrous cycle are to be synchronised, two injections will be required with an
interval of 10-12 days between injections. It is recommended that animals be
served/inseminated at the oestrus following treatment, i.e. at 72 hours after
the second injection. If double insemination is preferred, this should take
place at 72 and 96 hours after the second injection. Alternatively treatment
may be used in conjunction with GnRH (see Further information).
Treatment of sub-oestrus: this condition is found in lactating cows at the peak
of production. Animals may have normal cyclical ovarian activity, but may not
show any outward signs of oestrus. Having confirmed the presence of a
corpus luteum, treatment will cause luteal regression followed by oestrus in 2-
4 days.
Induction of abortion: The product can be used to induce abortion in cattle
and mares. Animals may be treated from 1 week up to 5 months after
mesalliance. Following luteal regression, abortion will usually occur within 7
days. In some cases, particularly those later on the pregnancy, a second or
third treatment may be required.

Revised: March 2012
AN: 00627/2011
Induction of parturition: in cattle, treatment may be used to initiate labour after
the 270th day of pregnancy. Calving may be expected within 3 days of
treatment. In pigs, the product may be used on or after the 113th day of the
gestation period. Parturition will normally follow within 48 hours.
It may also be used to induce parturition in the mare. Treatment must occur
on or after the 330th day of pregnancy and the mare must show relaxed pelvic
ligaments and functional udder with colostrum. Following treatment parturition
may be expected within a few hours.
Treatment of anoestrus: a persistent corpus luteum, particularly during
lactation may result in an anoestral mare. The product may be used to cause
luteal regression; oestrus and ovulation will then follow usually within 4-8 days
of treatment.
Treatment of endometritis or pyometra in cows: The luteolytic effect induces
oestrus which will aid the expulsion of uterine discharge. A single injection of
2 ml should be given; intransigent cases may require a repeat treatment after
10-14 days or alternative therapies should be considered.
Further information
Prosolvin can be used as part of a 10-day GnRH/prostaglandin/GnRH oestrus
synchronisation and insemination regime to increase submission rates and
significantly reduce the calving to conception interval. The use of GnRH 7
days prior to Prosolvin increases the proportion of cows able to respond to the
prostaglandin and co-ordinates a new follicular wave so more cows will
ovulate during a shorter time after Prosolvin. A second GnRH treatment after
the prostaglandin further tightens synchrony of ovulation in relation to the
service time.
The Intervet GnRH/prostaglandin/GnRH regime (Intercept™) for breeding
dairy cows at a pre-planned time without the need for specific heat detection
is summarised below:
Day 0 GnRH (2.5 ml)
Day 7 Prosolvin (2 ml)
Day 9 GnRH (2.5 ml) 54-56 hours post prostaglandin or at AI if sooner
Day 10 AI 72 hours post prostaglandin or at observed heat if sooner.

When using the Intercept fixed time insemination regime, it is recommended
that cows showing signs of oestrus after prostaglandin treatment should be
inseminated when observed in oestrus rather than completing the
synchronisation programme.
Trials have shown that for cows holding to their first service, use of a
GnRH/prostaglandin/GnRH regime can improve the calving to conception
interval by 11 days when compared to controls. When including all services,
the calving to conception interval was shown to be improved by 7 days

Revised: March 2012
AN: 00627/2011