POM-V Prescription Required

Primun Salmonella E Lyophilisate for Use in Drinking Water for Chickens

Active ingredient: Salmonella enterica subsp. enterica

Form

Lyophilisate

Species

Chickens

Manufacturer

Laboratorios Calier, S.A.

VMD MA No.

20634/5002

What it's used for

Active immunisation of chickens to reduce colonisation of internal organs (spleen, liver, caeca and ovaries) and faecal excretion of Salmonella Enteritidis...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Primun Salmonella E Lyophilisate for Use in Drinking Water for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Active immunisation of chickens to reduce colonisation of internal organs (spleen, liver,
caeca and ovaries) and faecal excretion of Salmonella Enteritidis field strains.
Onset of immunity: 14 days after 1
st
vaccination and 4 weeks after the 3
rd
vaccination.
Duration of immunity: 80 weeks after the 3
rd
vaccination, when used according to the
recommended vaccination schedule.

None.

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See also section 16 of the package
leaflet for contact details.

Vaccinate healthy animals only.
The efficacy of the vaccine has not been investigated in the presence of maternally
derived antibodies.

Issued: March 2024
AN: 01456/2022

The differentiation between vaccine and field strains is done by means of an antibiogram.
In contrast to field strains, vaccine strains are sensitive to erythromycin (recommended
concentration 15-30 µg/ml) and resistant to streptomycin and rifampicin (recommended
concentration 200 µg/ml).
Depending on the test system used, oral vaccination may result in low seropositive
reactions of individual birds in a flock. Since serological monitoring is a flock
test only, positive findings have to be confirmed, e.g., by bacteriology.
Special precautions for use in animals
Not tested in ornamental and pure-bred poultry.
The vaccine strain may spread to susceptible birds in contact with vaccinates by
shedding. Vaccinated birds shed the vaccine strain until 21 days after the first
vaccination. Susceptible birds in contact with vaccinates after the first vaccination may
shed the vaccine strain until 14 days after vaccination. Level and duration of spread of
the vaccine strain markedly decreases with subsequent vaccinations. Appropriate
veterinary and husbandry measures should be taken to avoid spread of the vaccine strain
to susceptible species.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Personal protective equipment consisting of gloves should be worn when handling the
veterinary medicinal product.
Open bottle under water to avoid aerosols. Disinfect and wash hands after handling
vaccine. Do not ingest.
In case of accidental ingestion, seek medical advice immediately and show the package
leaflet or the label to the physician.
The vaccine strain is sensitive to a number of antibiotics including quinolones
(ciprofloxacin). The vaccine strain can be found in the environment for up to 14 days.
Personnel involved in attending vaccinated chickens should follow general hygiene
principles (changing clothes, wearing gloves, cleaning and disinfection of boots) and take
particular care in handling animal waste and bedding materials from recently vaccinated
chickens.
Immunocompromised persons are advised to avoid contact with the vaccine and
vaccinated animals during handling and 28 days following vaccination.
Special precautions for the protection of the environment:
Not applicable.
Other precautions
Not applicable.

Issued: March 2024
AN: 01456/2022

The vaccine strain is highly sensitive to chemotherapeutics as quinolone antibiotics and
has increased sensitivity to erythromycin, chloramphenicol and doxycycline detergents
and environmental noxae. This product can be administered 3 days after or before the
administration of these chemotherapeutics which are effective against
is inevitable, the flock must be re-immunised.
The efficacy of this product can be compromised by the simultaneous use of live vaccines
against Gumboro disease,
evaluation by the responsible veterinarian, regarding the administration of other vaccines
before and after of this immunological product during the first days of life, is
recommended.

Store in a refrigerator (2 °C – 8 °C).
Do not freeze.
Protect from light.

Meat and offal: 28 days after 1
st
, 2
nd
and 3
rd
vaccination.
5. IMMUNOLOGICAL PROPERITES
Pharmacotherapeutic group: Immunologicals for Aves, live bacterial vaccines for
domestic fowls.
ATCvet code: QI01AE01 (Salmonella).
To stimulate active immunity to
is a natural metabolic drift mutant, i.e., it lacks or does not express certain metabolic
pathways which result in attenuation. The genetic basis results in defective ribosomal
protein S12 affecting polypeptide synthesis (streptomycin resistance) and defective RNA
polymerase affecting transcription of DNA to RNA (rifampicin resistance).
The vaccine strain also has attenuations that increase the permeability of the cell
membrane for harmful agents such as detergents and antibiotics. This means the strain
has poor survival in the environment and is highly sensitive to fluoroquinolones and
unlike field strains is sensitive to erythromycin.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.