Porcilis PRRS Lyophilisate and Solvent for Suspension for Injection for Pigs
Active ingredient: Porcine respiratory and reproductive syndrome virus
Form
Injection
Species
Manufacturer
Intervet International B.V.
VMD MA No.
06376/5026
What it's used for
For active immunisation of clinically healthy pigs in a PRRS virus contaminated environment, to reduce viraemia caused by infection with European strains o...
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Porcilis PRRS Lyophilisate and Solvent for Suspension for Injection for Pigs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
environment, to reduce viraemia caused by infection with European strains of PRRS virus.
Specific claims
For finishing pigs, the effect of the virus on the respiratory system is most relevant. A
significant improvement of rearing results (reduced morbidity due to PRRS infection, and a
better daily growth and feed conversion) until the end of the fattening period was observed
in vaccinated pigs during field trials, particularly in piglets vaccinated at 6 weeks of age.
For breeding pigs, the effect of the virus on the reproductive system is most relevant.
Revised: December 2024
AN: 03193/2024Page 2 of 8
A significant improvement of the reproductive performance in PRRS virus contaminated
environments and a reduction of transplacental virus transmission after challenge was
observed in vaccinated pigs.
Onset of immunity: 28 days post vaccination.
Duration of immunity: 24 weeks post vaccination.
established through reliable diagnostic methods.
Very common
(>1 animal / 10 animals treated):
Injection site lump.
Rare
(1 to 10 animals / 10,000 animals treated):
Hyperthermia
, hypersensitivity reactions
(including dyspnoea, hyperaemia,
decubitus, muscle tremor, excitation,
vomiting).
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Anaphylactic-type reactions.
1
After intradermal vaccination a small firm injection site lump (maximum 1.5 cm in
diameter) is observed and is indicative of the appropriate vaccination technique. This lump
is generally seen for less than 14 days but may occasionally persist for 29 days or longer.
After intramuscular vaccination.
These signs disappear spontaneously and totally within a few minutes after vaccination.
Fatal outcome of anaphylactic-type reactions has been reported very rarely.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also the last section of the
package leaflet for respective contact details.
boars. Do not use in herds where a PRRS eradication programme based on serology has
been adopted.
Maternally derived antibodies may interfere with the response to vaccination.
Vaccinate healthy animals only.
Special precautions for use in animals:
Care should be taken to avoid the introduction of the vaccine strain into an area where
PRRS virus is not already present. The vaccine virus may spread to pigs in contact during
5 weeks after vaccination. The most common spreading route is via direct contact, but
spreading via contaminated objects or via the air cannot be excluded. Care should be
taken to avoid spread of vaccine virus from vaccinated animals to unvaccinated animals
(e.g. naïve pregnant sows) that should remain free from PRRS virus. Do not use in boars
producing semen for seronegative herds, as PRRS virus may be excreted in semen for
many weeks.
Do not routinely rotate two or more commercial PRRS MLV vaccines based on different
strains in a herd.
In order to limit the potential risk of recombination between PRRS MLV vaccine strains of
the same genotype, do not use different PRRS MLV vaccines based on different strains of
the same genotype on the same farm at the same time. In the case of transitioning from
one PRRS MLV vaccine to another PRRS MLV vaccine, a transition period should be
respected between the last administration of the current vaccine and the first
administration of the new vaccine. This transition period should be longer than the
shedding period of 5 weeks following vaccination.
PRRS virus-naïve breeding animals (e.g. replacement gilts from PRRS virus-negative
herds) which are introduced into a PRRSV-infected herd should be vaccinated prior to first
insemination. Vaccination should preferably be done in a separated quarantine unit. A
transition period should be respected between vaccination and moving the animals to the
breeding unit. This transition period should be longer than the shedding phase of 5 weeks
following vaccination.
Revised: December 2024
AN: 03193/2024Page 3 of 8
Vaccination should aim to achieve a homogenous immunity in the target population at farm
level.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
weeks of age onwards, which demonstrate that this vaccine can be mixed with Porcilis M
Hyo.
Safety and efficacy data are available for both routes of administration in finishing pigs
from 3 weeks of age onwards, which demonstrate that this vaccine can be given with
Porcilis PCV M Hyo, with Porcilis Lawsonia, or with a mixture of Porcilis PCV M Hyo and
Porcilis Lawsonia, at the same time, but at separate sites (preferably at the opposite side
of the neck).
In individual pigs the temperature increase after associated use may commonly exceed
2 °C. The temperature returns to normal from 1 to 2 days after the peak temperature is
observed. Transient local injection site reactions, which are restricted to a slight injection
site lump (maximum 2 cm diameter), may commonly occur from 5 days after vaccination
onwards, after intradermal and after intramuscular vaccination. These lumps may
occasionally persist until 29 days after vaccination or longer. Hypersensitivity reactions
after vaccination may occur uncommonly.
Safety and efficacy data are available in pigs from 3 weeks of age onwards which
demonstrate that this vaccine can be administered intradermally non-mixed with Porcilis
PCV ID alone or with Porcilis PCV ID mixed with Porcilis Lawsonia ID and/or non-mixed
with Porcilis M Hyo ID ONCE providing that administration site of non-mixed vaccines is
separated by at least 3 cm. Adverse events are as described in section 4.6, except for
injection site lumps of up to 2.5 cm can be observed in individual pigs. These lumps may
last 5 weeks and are very commonly accompanied by redness and crusts. Hyperthermia
on the day of vaccination (mean 0.3 °C, individual pigs up to 1.2 °C) is common. Lying
down and malaise can be uncommonly observed in vaccinated pigs. The product literature
of respective products should be consulted before administration in association with
Porcilis PRRS. No information is available on the safety and efficacy of the administration
of Porcilis PRRS in association with the above-mentioned products in breeding animals or
during pregnancy.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product, except the products mentioned above. A decision to
use this vaccine before or after any other veterinary medicinal product therefore needs to
be made on a case by case basis.
Protect from light.
Solvent: store below 25 C.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Pig, live PRRS viral vaccine
ATCvet code: QI09AD03
Revised: December 2024
AN: 03193/2024Page 6 of 8
Intramuscular or intradermal administration of Porcilis PRRS results in the production of
specific antibodies and active immunisation against infection caused by European strains
of Porcine Reproductive and Respiratory Syndrome virus. Immunity is enhanced by the
adjuvant α-tocopheryl
On the basis of antibodies induced by vaccination, it is not possible to discriminate
vaccinated animals from those naturally infected with European strains of PRRS virus.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Porcine respiratory and reproductive syndrome virus
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Ingelvac PRRSFLEX EU Lyophilisate and Solvent for Suspension for Injection for Pigs
POM-VBoehringer Ingelheim Vetmedica GmbH
Ingelvac PRRSFLEX EU Lyophilisate and Solvent for Suspension for Injection for Pigs
POM-VBoehringer Ingelheim Vetmedica GmbH
Porcilis PRRS Lyophilisate and Solvent for Suspension for Injection for Pigs
POM-VIntervet International B.V.
Progressis Emulsion for Injection
POM-VCeva Sante Animale
Progressis Emulsion for Injection
POM-VCeva Sante Animale
ReproCyc PRRS EU Lyophilisate and Solvent for Suspension for Injection for Pigs
POM-VBoehringer Ingelheim Vetmedica GmbH
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