Permaway 600 mg Intramammary Suspension for Cattle

it could select antimicrobial-resistant bacteria within the intestinal microbiota of the calf
and increase the faecal shedding of these bacteria.
The efficacy of the product has only been established for target organisms listed in
section 4.2.
Consequently, the occurrence of a severe mastitis after drying-off (sometimes fatal)
due to other organisms, especially , is possible. To reduce
this risk it is important to observe strict aseptic technique for the administration of the
product.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-
reactions to cephalosporins and vice versa. Allergic reaction to these substances may
occasionally be serious.
People with known hypersensitivity to penicillins or cephalosporins should avoid any
contact with the veterinary medicinal product.
Handle this product with great care to avoid exposure. Wear gloves during
administration of the product and wash hands after use.
In case of accidental contact with skin or eyes, wash immediately with clean water.
If you develop symptoms following exposure, such as a skin rash, you should seek
medical advice and show the physician this warning. Swelling of the face, lips or eyes
or difficulty with breathing are more serious symptoms and require urgent medical
attention.

Revised: September 2025
MA split from NI following AN: 01525/2025
4.6 Adverse reactions (frequency and seriousness)
Immediate allergic reactions have been described in some animals (agitation, tremor,
edema of the udder, eyelids and lips) which can lead to the death of the animals.
4.7 Use during pregnancy, lactation or lay
Do not use this medicinal product in the lactating cows.
The product is intended to be used during gestation. The safety of the medicinal
product in dairy cows during gestation has not been shown. However, the amounts of
cloxacillin absorbed by the intramammary route being low, the use of this drug during
gestation does not pose any particular problem.
4.8 Interaction with other medicinal products and other forms of interaction
The safety of the concomitant use of this medicinal product with other intramammary
medicinal products has not been established, so simultaneous use is discouraged.
4.9 Amounts to be administered and administration route
For single intramammary use
600 mg of cloxacillin i.e. the content of one syringe should be infused once into each
quarter via the teat canal immediately after the last milking of the lactation.
Milk out thoroughly before starting administration. Before administering the medicinal
product, the teats should be thoroughly cleaned and disinfected, and care should be
taken to avoid contamination of the syringe nozzle. Administer the full content of a
syringe in each quarter. Massage after administration. After administration it is
recommended to immerse the teat in an approved disinfectant bath. Do not milk after
treatment.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No adverse reactions are expected in case of accidental overdose.
4.11 Withdrawal period
Meat and offal: 28 days
Milk: Interval between treatment and calving is 42 days or longer: 4 days after
calving.
Interval between treatment and calving is less than 42 days: 46 days after treatment.

5.