POM-V Prescription Required

Pathocef 250 mg Intramammary Suspension

Active ingredient: Cefoperazone

Form

Intramammary

Species

Cattle

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5202

What it's used for

PATHOCEF Intramammary Suspension is indicated for the treatment of clinical mastitis in lactating cows. Clinical mastitis caused by a wide range of organis...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Cefoperazone

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Pathocef 250 mg Intramammary Suspension — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

PATHOCEF Intramammary Suspension is indicated for the treatment of
clinical mastitis in lactating cows.
Clinical mastitis caused by a wide range of organisms including the following
pathogens have been shown to respond to treatment with cefoperazone.
- Streptococcus dysgalactiae
- Streptococcus uberis
- Streptococcus agalactiae
- Staphlococcus aureus (including penicillinase producing strains)
- Escherichia coli
- Arcanobacterium (Actinomyces) pyogenes
- Pseudomonas aeruginosa
- Micrococcus
- Klebsiella spp.
The single dose treatment with PATHOCEF Intramammary Suspension has
been shown to provide a high response rate in mastitis caused by major
pathogens.

Revised: May 2025
MA split from NI MA following AN: 00175/2025Page 2 of 4

The contents of one syringe should be injected into the infected quarter
immediately after milking. Before injection the teat should be thoroughly
cleaned and disinfected.

The product is contraindicated in animals which are known to have
exhibited allergic reactions to cephalosporins or to have severe
disturbance of kidney function.
There is a rare possibility of cross reaction with other beta-lactam antibiotics.

None.

It is not envisaged for this product to be administrated to species other than
lactating cattle.

(i) Special precautions for use in animals
None
(ii) Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy)
following injection, inhalation, ingestion or skin contact.
Hypersensitivity to penicillins may lead to cross-reactions to
cephalosporins and vice-versa. Allergic reaction to these substances
may occasionally be serious.
Do not handle this product if you know you are sensitised, or if you
have been advised not to work with such preparations.
Handle this product with great care to avoid exposure, taking all
recommended precautions.
If you develop symptoms, such as a skin rash, you should seek
medical advice and show the doctor this warning or the package
leaflet. Swelling of the face, lips or eyes or difficulty with breathing are
more serious symptoms and may require urgent medical attention.
Wash hands after use.

Cefoperazone is not compatible with aminoglycoside antibiotic such as
streptomycin, neomycin and gentamycin. The simultaneous administration of
possibly nephrotoxic drugs may prolong the elimination of cefoperazone.

Do not store above 25°C.
For single use only.

Meat: 2 days
Milk: 72 hours
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.