POM-V Prescription Required Companion Animal

Orbenin Ophthalmic Ointment 16.67% w/w Eye Ointment

Active ingredient: Cloxacillin

Form

Cream

Species

Cats Cattle Dogs Horses Sheep

Manufacturer

Zoetis Belgium S.A.

VMD MA No.

60021/3090

What it's used for

For the treatment of ocular infections in cattle, sheep, horses, dogs and cats where susceptible organisms, such as Staphylococcus aureus (including beta-...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Cloxacillin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Orbenin Ophthalmic Ointment 16.67% w/w Eye Ointment — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of ocular infections in cattle, sheep, horses, dogs and cats
where susceptible organisms, such as Staphylococcus aureus (including beta-
lactamase producing strains), and Branhamella ovis, are
suspected or anticipated as pathogens. A particular indication is treatment of
New Forest Disease in cattle.

For topical application only. The tube has a nozzle adaptor but it is
recommended that the short nozzle is used.
The short nozzle is selected as follows:
Hold top section of the white cap between forefingers and thumb. Bend top of
cap and break to remove. Do not touch the nozzle with fingers.
Evert the lower eyelid and instil the ointment liberally into the lower conjunctival
sac for example:
Cattle and horses
/4 -
/2 tube per eye.
Sheep
/4 tube per eye.
Dogs and cats
/10 tube per eye.
For treatment of New Forest Disease in cattle and contagious ophthalmia in
sheep one application only is normally required, but treatment may be repeated
at intervals of 48 hours in cattle and 72 hours in sheep if necessary. Treatment
should be repeated at 24 hourly intervals in dogs, cats and horses.

Revised: May 2025
AN: 00170/2025
Even if only one eye is affected, it may be advisable to treat both eyes; the
unaffected eye first to avoid transmitting the infection.

None.

None known.

For external use only.

(i) Special precautions for use in animals

Revised: May 2025
AN: 00170/2025
Care should be taken to avoid contamination of the contents during use.
(ii) Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy)
following injection, inhalation, ingestion, or skin contact. Hypersensitivity
to penicillins may lead to cross reactions to cephalosporins and vice
versa. Allergic reactions to these substances may occasionally be
serious.
Do not handle this product if you know you are sensitised, or if you have
been advised not to work with such preparations. Handle this product
with great care to avoid exposure, taking all recommended precautions.
If you develop symptoms following exposure, such as a skin rash, you
should seek medical advice and show the doctor this warning. Swelling
of the face, lips or eyes, or difficulty with breathing are more serious
symptoms and require urgent medical attention.
Wash hands after use.

None known.

Do not store above 25
°
C.

Revised: May 2025
AN: 00170/2025
Any contents remaining 28 days after the tube was first opened should be
discarded.

Animals must not be slaughtered for human consumption during treatment.
Cattle, sheep and horses may be slaughtered for human consumption only after
the last treatment.
Milk: Cattle and sheep: Zero hours.
Meat: Cattle, sheep and horses: Zero days.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.