Novocillin LC 1000 mg Intramammary Suspension for Lactating Cows

it could select antimicrobial-resistant bacteria within the intestinal microbiota of the calf
and increase the faecal shedding of these bacteria.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead to cross
reactions to cephalosporins and vice versa. Allergic reactions to these substances may
occasionally be serious.
Do not handle this product if you know you are sensitised to penicillins or
cephalosporins or if you have been advised not to work with such preparations.
Handle this product with great care to avoid exposure by accidental contact with the
skin or eyes. Persons developing a reaction after contact with the product should avoid
handling the product (and other penicillin and cephalosporin containing products) in
future.
It is recommended to wear gloves when handling or administering the product. Wash
exposed skin after use. In case of any eye contact, wash the eyes thoroughly with
copious amounts of clean running water.
If you develop symptoms following exposure such as skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes or
difficulty with breathing are more serious symptoms and require urgent medical
attention.
Wash hands after use.
4.6 Adverse reactions (frequency and seriousness)
Hypersensitivity reactions (i.e., allergic skin reactions, anaphylaxis) have been
reported very rarely in spontaneous reports. If such a reaction occurs, the current
treatment should be stopped immediately and an appropriate symptomatic treatment
be initiated.
In case of anaphylaxis: adrenaline (epinephrine) and glucocorticoids i.v.
In case of allergic skin reactions: antihistamines and/or glucocorticoids.
The frequency of adverse reactions is defined using the following convention:

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- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
4.7 Use during pregnancy, lactation or lay
The product is intended for use during lactation.
4.8 Interaction with other medicinal products and other forms of interaction
Regarding antibacterial effects, a potential antagonism exists between penicillins and
chemotherapeutic agents with rapid bacteriostatic action (tetracyclines, macrolides,
lincosamides).
4.9 Amounts to be administered and administration route
For intramammary use.
1000 mg oxacillin sodium per affected udder quarter, corresponding to 10 g of the
product (full content of one syringe) per affected udder quarter. Three consecutive
treatments must be administered, at 24-hour intervals.
Immediately prior to the individual treatment, all udder quarters should be milked out
carefully. The teat tip should be cleaned and disinfected, followed by intramammary
administration of the content from one intramammary syringe per affected udder
quarter.
If no significant improvement of the clinical condition is observed within 2 days of
treatment, the diagnosis should be reviewed.
Shake the product before use.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
No information available.
4.11 Withdrawal period(s)
Meat and offal 6 days
Milk 144 hours (6 days)
5.