POM-V Prescription Required Companion Animal

Norodine 24 Solution for Injection

Active ingredients: Sulfadiazine, Trimethoprim

Form

Injection

Species

Cats Cattle Dogs Horses Pigs

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/4061

What it's used for

Norodine 24 Injectable Solution is indicated in the treatment of systemic infections caused by or associated with organisms sensitive to the Trimethoprim:S...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Sulfadiazine + Trimethoprim

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Norodine 24 Solution for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Norodine 24 Injectable Solution is indicated in the treatment of systemic
infections caused by or associated with organisms sensitive to the
Trimethoprim:Sulfadiazine combination. The spectrum of activity includes both
Gram-positive and Gram-negative organisms including:
Actinobacilli
Actinomycae
Bordetella spp
Brucella
Corynebacteria
Escherichia coli
Haemophilus spp
Klebsiella spp
Pasteurella spp

Revised: January 2026
AN: 03001/2025
Pneumococci
Proteus
Salmonella spp
Staphylococci
Streptococci
Vibrio

Cattle and Pigs:
The recommended dose rate is 15 mg of active ingredients per kilogram
bodyweight (1 ml per 16 kg bodyweight) by intramuscular or slow intravenous
injection.
Norodine 24 Injectable Solution may be administered by intravenous injection
when rapid blood levels of trimethoprim and Sulfadiazine are required.
Horses
The recommended dose rate is 15 mg of active ingredients per kilogram
bodyweight (1 ml per 16 kg bodyweight), by slow intravenous injection.
Dogs and Cats:
The recommended dose rate is 30 mg of active ingredients per kilogram
bodyweight (1 ml per 8 kg bodyweight), by subcutaneous injection only.
The recommended site in dogs is the loose skin at the top of the neck.
A single injection may be sufficient in uncomplicated conditions, but in severe
infections it may be repeated daily until 2 days after symptoms resolve, up to a
maximum of 5 days.
An appropriately graduated syringe must be used to allow accurate
administration of the required dose volume. This is particularly important when
injecting small volumes.

Revised: January 2026
AN: 03001/2025

Norodine 24 Injectable Solution should not be given by routes other than those
recommended. Not to be administered intraperitoneally, intra-arterially or
intrathecally.
Do not administer to animals with known sulphonamide sensitivity, severe liver
parenchymal damage or blood dyscrasias.

Anaphylactic shock, potentially fatal, has been observed on rare occasions
following administration of potentiated sulphonamide preparations, particularly by
the intravenous route. Veterinary surgeons should be mindful of this possibility
during the injection process.

None known

Special precautions for use in animals
For intravenous administration the product should be warmed to body
temperature and injected slowly over as long a period as is reasonably practical.
At the first sign of intolerance the injection should be interrupted and shock
treatment initiated.
Adequate drinking water should be available during the therapeutic effect of the
product.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Care should be taken to avoid accidental injection and contact with the skin.
Wash hands after use.
Sulphonamides may cause hypertensitivity (allergy) following injection, inhalation,
ingestion or skin contact. Hypesensitivity to sulphonamides may lead to cross
reactions with other antibiotics. Allergic reactions to these substances may
occasionally be serious.
1. Do not handle this product if you know you are sensitive to sulphonamides.
2. If you develop symptoms following exposure such as a skin rash, you should
seek medical advice and show the doctor this warning.
3. Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone
have shown evidence of foetotoxic effects. Women of childbearing age,
pregnant women or women suspected of being pregnant should use the
veterinary medicinal product with serious caution to avoid accidental self-
injection.

Revised: January 2026
AN: 03001/2025

Do not administer to horses exhibiting drug-induced cardiac arrhythmias. Such
arrhythmias may be associated with the administration of certain anaesthetic and
sedative agents.

Do not store above 25ºC.
Protect from light.
Protect from freezing.
Following withdrawal of the first dose use the product within 28 days. Discard
unused material.
Crystallisation can occur at extremes of temperature. Crystals can be redissolved
by gentle warming and / or agitation.

Not to be used for horses intended for human consumption. Treated horses may
never be slaughtered for human consumption. The horse must have been
declared as not intended for human consumption under national horse passport
legislation.
Cattle:Meat – 12 days
Milk – 48 hours
Pigs: Meat – 20 days
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.