Nobivac L4 Suspension for Injection for Dogs
Active ingredients: Leptospira australis, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae
Form
Injection
Species
Manufacturer
MSD Animal Health UK Limited
VMD MA No.
01708/5048
What it's used for
For active immunisation of dogs against and L. kirschneri: Serogroup/ Serovar Indication Canicola/ Canicola Icterohaem orrhagiae/ Icterohaem orrhagiae Icte...
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-
1
Ask your vet for a written prescription
They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
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2
Fill it at a registered online retailer
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Nobivac L4 Suspension for Injection for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
Serogroup/
Serovar
Indication
Canicola/
Canicola
Icterohaem
orrhagiae/
Icterohaem
orrhagiae
Icterohaem
orrhagiae/
Copenhage
ni
Australis/
Bratislava
Grippotypho
sa/
Grippotypho
sa
Grippotyp
hosa/
Bananal/Li
angguang
InfectionReductionReductionReductionReductionReductionReductionUrinary
Excretion
ReductionReduction
ReductionPrevention
Prevention
Reduction
MortalityPrevention
Prevention
Prevention
---Clinical SignsReduction
Reduction
Reduction
Reduction
Reduction
1,3
Reduction
Renal
Carriage
PreventionReduction
Reduction
-Prevention
Prevention
Renal
Lesions
Reduction-Reduction
-Reduction
Prevention
1
Demonstrated 3 weeks after primary vaccination and not during challenge experiments for duration
of immunity;
Demonstrated 6 weeks after primary vaccination and not during challenge
experiments for duration of immunity;
Based on reduction of pyrexia.
Onset of immunity: 3 weeks.
Duration of immunity: 1 year.
Very common
(>1 animal / 10 animals treated):
Injection site swelling
,
Injection site nodule
,
Injection site pain
,
Elevated temperature
,
Decreased activity
,
Decreased appetite
4.
Very rare
(<1 animal / 10,000 animals
treated, including isolated reports):
Hypersensitivity reaction
,
Immune mediated haemolytic anaemia,
Immune mediated thrombocytopenia,
Immune mediated polyarthritis.
5 cm; subsides within 14 days; may peak up to 6.5 cm on the day of vaccination.
Subsides within 14 days.
≤ 1.4 °C, up to 3 days.
In pups.
Reactions are transient. This includes anaphylaxis (sometimes fatal). If such
reaction occurs, appropriate treatment should be administered without delay.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also section 16 of the package leaflet for contact
details.
Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Avoid accidental self-injection or contact with the eyes. In case of ocular irritation
seek medical advice immediately and show the package leaflet or the label to the
physician.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.
Revised: December 2025
AN: 02357/2024
mixed and administered with vaccines in the Nobivac range containing canine
distemper virus, canine adenovirus type 2, canine parvovirus (strain 154) and/or
canine parainfluenza virus components for subcutaneous administration. The product
information of the relevant Nobivac vaccines should be consulted before
administration of the mixed product. When mixed with these Nobivac vaccines, the
demonstrated safety and efficacy claims for Nobivac L4 are no different from those
described for Nobivac L4 alone. When mixed with Nobivac vaccines containing
canine parainfluenza virus at annual revaccination, it has been established that there
is no interference with the anamnestic response induced by the injectable canine
parainfluenza virus component.
Safety and efficacy data are available which demonstrate that this vaccine can be
administered on the same day but not mixed with vaccines in the Nobivac range
Revised: December 2025
AN: 02357/2024
containing Bordetella bronchiseptica and/or parainfluenza virus components for
intranasal administration.
Safety data are available which demonstrate that this vaccine can be administered at
the same time but not mixed with the inactivated vaccine in the Nobivac range
against .
When this vaccine is administered in association with the inactivated vaccine in the
Nobivac range against Bordetella bronchiseptica
response data and other immunity data of this vaccine are the same as when this
vaccine is administered alone.
Safety and efficacy data are available which demonstrate that this vaccine can be
administered at the same time but at different administration sites with vaccine in the
Nobivac range against rabies, although this may, in some instances, lead to vomiting.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product except the products mentioned above. A
decision to use this vaccine before or after any other veterinary medicinal product
therefore needs to be made on a case by case basis.
Do not freeze.
Protect from light.
Revised: December 2025
AN: 02357/2024
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunologicals for Canidae, inactivated bacterial
vaccines.
ATCvet code: QI07AB01.
To stimulate active immunity in dogs against L. interrogans serogroup Canicola
serovar Canicola, L. interrogans serogroup Icterohaemorrhagiae serovar
Icterohaemorrhagiae, L. interrogans serogroup Icterohaemorrhagiae serovar
Copenhageni, interrogans serogroup Australis serovar Bratislava, L. kirschneri
serogroup Grippotyphosa serovar Grippotyphosa and L. kirschneri
Grippotyphosa serovar Bananal/Lianguang.
It was demonstrated that the vaccine prevents mortality and reduces clinical signs,
urinary excretion, infection and renal lesions against L. interrogans serogroup
Australis serovar Australis at three weeks after vaccination.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Leptospira australis
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Canigen L4, Suspension for Injection for Dogs
POM-VIntervet International B.V.
Canigen Lepto 4, Suspension for Injection for Dogs
POM-VMSD Animal Health UK Limited
Nobivac L4 Suspension for Injection for Dogs
POM-VIntervet International B.V.
Porcilis Ery+Parvo+Lepto Suspension for Injection for Pigs
POM-VIntervet International B.V.
Porcilis Ery+Parvo+Lepto Suspension for Injection for Pigs
POM-VIntervet International B.V.
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