Nobilis Ma5 + Clone 30 Lyophilisate for Oculonasal Suspension/use in Drinking Water for Chickens

- Spray vaccination
- Drinking water application
- Oculonasal application
The vaccine can be administered by (coarse) spray or oculonasal use or by in
drinking water use.
For oculonasal use a special solvent, Nobilis Diluent Oculo Nasal, is available.
Administration by coarse spray or the oculonasal route is the method of choice when
vaccinating young birds; fine spray for older birds.
The amount of volume used for application depends on the equipment used and the
age of the animals to be vaccinated.
The vaccine is safe to use from 1 day of age onwards.
The optimum time and method of administration depend largely on the local situation.
Where necessary the advice of a veterinary surgeon should be sought.
The vaccine may be delivered as a freeze-dried cake in a glass vial or as freeze-
dried spheres in cups. In case of the product presented in cups, do not use the
product if the contents are brownish and stick to the container as this indicates that
the integrity of the container has been breached. Each container should be used
immediately and completely after opening.
The vials should be opened under water or the content of the cup(s) should be
poured into the water. In both cases mix the water containing the vaccine well before
use. After reconstitution the suspension looks clear.
Spray application
The vaccine should be dissolved in cool, clean water which is free of iron and
chlorine. The appropriate number of vials should be opened under the surface of the
water or the content of the cup(s) should be poured into the water. In both cases mix
the water containing the vaccine well before use. After reconstitution the suspension
looks clear. The volume of water for reconstitution should be sufficient to ensure an
even distribution when sprayed onto the birds. This will vary according to the age of
the birds being vaccinated and the management system. The vaccine medicated
water should be spread evenly over the correct number of birds, at a distance of 30 –
40 cm, (12 – 16”), preferably when the birds are sitting together in dim light. The
spray apparatus should be free from sediments, corrosion and traces of disinfectants
(preferably use it for vaccination purposes only). Aerosol generators should be used
only when it is known to be safe to the birds.
Number
of doses
Day-old birds
(Nozzle producing coarse
droplets)
Older birds
(Nozzle producing fine
droplets)
10000.25 Litre1 Litre
Oculonasal use
Dissolve the vaccine in Nobilis Diluent Oculo/Nasal or physiological saline solution
(usually 30 ml per 1000 doses) and administer by means of a standardised dropper.
One drop should be applied from a height of a few centimeters onto one nostril or
one eye. The handler should ensure that the nasal drop is inhaled by the bird.
Drinking water application
The vaccine is presented in vials under vacuum. The vials should be opened under
water or the content of the cup(s) should be poured into the water. Measure the
correct volume of water for the number of birds to be vaccinated (see below), add 20
grams skimmed milk powder or 500 ml liquid skimmed milk per 10 litres, allow to
stand for 15–30 minutes, then open the correct number of containers of vaccine
under the surface of the water (vials) or into the water (cups). All containers used
should be clean and free from any traces of detergent or disinfectant. In both cases
mix the water containing the vaccine thoroughly with a clean stirrer, ensuring that all
containers used are emptied. After reconstitution the suspension looks clear. Offer to
birds immediately and ensure uptake of all the vaccine medicated water in 2 hours.
The vaccine should be dissolved in clean cold water, in which chlorine or metals can
neither be tasted nor smelled. Where water sanitisers are used consult the marketing
authorisation holder’s technical staff. Only skimmed milk should be used, as the fat in
whole milk may block the automatic drinking systems as well as reduce vaccine virus
efficacy.
The vaccine should be given in the early morning as this is the main period of
drinking or the cool period on a hot day. When vaccinating larger flocks, it is
advisable to start by dissolving only part of the vaccine. If vaccine is administered
through a central water supply or a proportioner, great care should be taken. For
numbers of birds between standard dosages, the next higher dosage should be
chosen.
Volumes of water for reconstitution of vaccine
The volume of water for reconstitution depends on the age of the birds and the
management practice.
Simple drinking troughs and fountains
The following are guidelines:
1000 doses/litre/age in days up to a volume of 20 litres per 1000 doses.
For heavy breeds, or in hot weather, the quantity of water may be increased up to 30
litres per 1000 doses. Where the number of birds is between the standard dosages,
the next higher dosage should be used.
Nipple drinkers
Drinker line management is known to have a significant effect on the viability of live
vaccine virus. The vaccine virus can deteriorate very rapidly and it is essential to
ensure that all birds received the correct dose.
Special care should be observed concerning the method of administration. For
example, small header tanks may require recharging with medicated water several
times during a 1 – 2 hour period.
Administration
Water should be withheld before vaccination. For recommendations see below under
‘Management’. Ensure that all medicated water is consumed within 1 – 2 hours. Turn
on mains water when all the vaccine water has been consumed. Always make sure
that there is food available when vaccinating.
Birds will not drink if they have no food to eat.
Management
Great care should be taken to ensure that all birds receive a full dose of vaccine
when the product is administered in drinking water. When used in chickens where
maternal antibody still exists, the way in which this vaccine is administered is critical.
The following points have been found to improve vaccine “take”:
1. Water withholding should be kept to a minimum, especially in broiler birds.
Approximately half an hour is all that is required if the following management
techniques are used.
2. Try to vaccinate at a time when birds are likely to be drinking, e.g. morning
time for broilers, when food is in the food tracks.
3. Turn the lights down low when the water is turned off. For bell drinkers, go
round the house emptying and cleaning the drinkers during the half-hour lights
low period. Mix up the vaccine according to the recommendations, and
towards the end of the half-hour water withholding period, go round all the
drinkers filling each with water containing vaccine. Leave the house and turn
the light up. The increased light intensity will stimulate the birds to look for
water and food. Therefore, it is important that food is available or the birds will
not be interested in drinking. In some cases, it helps to run food tracks at the
time the light intensity is increased.
For nipple lines a substantial volume of residual water may remain in the lines
after the half-hour water withholding/dark period. It is advisable to drain the
lines and prime with vaccine loaded water before allowing the birds to have
access to the drinker lines. Mix up the vaccine and apply to the header
tank(s). Calculate the volume of water that is left in the tank below the outlet
valve and make sure you add extra vaccine to this volume of water. For
example, if 10 litres remain below the outlet pipe and you are using 10
litres/1000 birds to vaccinate, add one extra vial of vaccine when mixing up
vaccine for that tank. The use of this extra vaccine is important.
4. Once the vaccine has been consumed, resume management practices as
normal. This approach to vaccination will ensure a more even vaccination of
the crop and will be less stressful to the birds. Performance should therefore
be less adversely affected.
For further information on use of a vaccine in specific circumstances or in conjunction
with other MSD vaccines consult the marketing authorisation holder’s technical staff.