Nimatek 100 mg/ml Solution for Injection for Dogs, Cats and Horses

For very painful and major surgical interventions, as well as for maintenance of
anaesthesia, a combination with injectable or inhalation anaesthetics is necessary.
As muscle relaxation required for surgical procedures cannot be achieved with
ketamine alone, additional muscle-relaxants should be used concomitantly. For
improvement of anaesthesia or prolongation of effect ketamine can be combined with
α2-receptor-agonists, anaesthetics, neuroleptanalgesics, tranquillisers and
inhalational anaesthetic agents. It should be noted that time-to-full-effect may be
prolonged when using the subcutaneous administration route in cats.

Special precautions for use in animals
A small proportion of animals have been reported to be unresponsive to ketamine as
an anaesthetic agent at normal dosages. Use of premedicants should be followed by
a suitable reduction in dosage.
Induction and recovery should be allowed to occur in quiet and calm surroundings.
As with all anaesthetics, animals should be fasted for an appropriate duration (as
determined by the responsible veterinary surgeon) prior to ketamine
anaesthesia.Atropine premedication may reduce salivation in cats. Since use of
atropine with alpha-2-agonists, which are often administered with ketamine, may
increase arterial blood pressure, heart rate and the incidence of arrhythmias, atropine
premedication should only be used according to a benefit:risk assessment by the
responsible veterinarian.
Muscular twitching and mild tonic convulsions have been reported in the cat at
recommended dose rates. These subside spontaneously but may be prevented by
use of acepromazine or xylazine premedication, or controlled by use of
acepromazine or ultra-short acting barbiturates in low doses.
In the cat and dog, the eyes remain open and the pupils dilated. The eyes may be
protected by covering with a damp gauze swab or using appropriate ointments.
Ketamine may exhibit pro-convulsant and anti-convulsant properties, and therefore
should be used with care in patients with seizure disorders.
Ketamine may increase intracranial pressure and therefore, may not be suitable for
patients with cerebrovascular insults.
When used in combination with other products, consult the contraindications and
warnings that appear on the relevant data sheets.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This is a potent drug. Particular care should be taken to avoid accidental self-
administration. Preferably use a guarded needle until the moment of injection.
People with known hypersensitivity to ketamine or any of the excipients should avoid
contact with the veterinary medicinal product.
Avoid contact with the skin and eyes. Wash any splashes from skin and eyes
immediately with large amounts of water.
Adverse effects on the foetus cannot be excluded. The veterinary medicinal product
should not be administered by pregnant women.
In case of accidental self-injection or if symptoms occur after ocular/oral contact,
seek medical advice immediately and show the package leaflet or the label to the
physician, but DO NOT DRIVE.

Amended pages: July 2023
AN. 00608/2022
Advice to doctors:
Do not leave patient unattended. Maintain airways and give symptomatic and
supportive treatment.
Special precautions for the protection of the environment:
Not applicable.