MS-H Vaccine Oculonasal Suspension

Do not use antibiotics with anti-Mycoplasma activity 2 weeks before or 4 weeks after
vaccination. Such antibiotics include e.g. tetracycline, tiamulin, tylosin, quinolones,
lincospectin, gentamicin or macrolide antibiotics.
Where antibiotics must be used, preference should be given to agents with no
antimycoplasma activity, such as penicillin, amoxicillin or neomycin. They should not
be given within 2 weeks after vaccination.
Vaccinate healthy animals only.

Special precautions for use in animals
All birds in a flock/common housed group must be vaccinated at the same time.
Only flocks with no antibodies to M. synoviae
should be carried out on -free birds at least 4 weeks before expected
exposure to virulent M. synoviae.
Pullets should first be tested for M. synoviae infection. Testing for the presence of
synoviae in the flock is normally by way of an indirect diagnostic assay (e.g. the rapid
serum agglutination test (RSAT) or ELISA) with blood samples being tested within 24
hours of collection. Testing by a direct diagnostic assay (e.g. PCR) for the presence
of M. synoviae is preferable due to the time required for seroconversion after
infection.
The vaccine strain can spread from vaccinated to unvaccinated birds, including wild
species. This may occur during the whole life of the vaccinated bird. Special
precautions should be taken to avoid spreading of the vaccine strain to other bird
species, and it is essential that all birds in the flock/common housed group are
vaccinated.
The vaccine strain can be detected in respiratory tract of the chickens until 55 weeks
after vaccination.
Distinguishing between field strains and the vaccine strain of M. synoviae can be
performed by Hammond classification or High Resolution Melt (HRM) testing by a
laboratory.
Infection with M. synoviae induces a transient positive antibody response to
Mycoplasma gallisepticum. Although no data are available on the matter, it is likely
that vaccination with this product will also induce a positive antibody response to
Mycoplasma gallisepticum and may therefore interfere with the serological monitoring
of Mycoplasma gallisepticum. If necessary, further differentiation of the 2
Mycoplasma species can be done by using PCR in a laboratory. Samples that can be
used for PCR include swabs taken from pathological sites such as trachea, palatine
cleft, air sacs or joints.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Personal protective equipment consisting of gloves and safety glasses should be
worn when handling the veterinary medicinal product.

Revised: December 2025
AN: 02593/2025
If vaccine is accidentally splashed into the operator’s eyes, the eyes and face should
be thoroughly washed with water to avoid any potential reaction to culture medium
constituents.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.