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Lincoral-S 222 mg/g + 444.7 mg/g Powder for Use in Drinking Water for Pigs and Chickens

Active ingredients: Lincomycin Hydrochloride, Spectinomycin Sulphate

Form

Powder

Species

Chickens Pigs

Manufacturer

Huvepharma NV

VMD MA No.

30282/5017

What it's used for

Chickens: For the treatment and metaphylaxis of chronic respiratory disease (CRD) caused by Mycoplasma gallisepticum and rate. The presence of the disease...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Lincoral-S 222 mg/g + 444.7 mg/g Powder for Use in Drinking Water for Pigs and Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Chickens:
For the treatment and metaphylaxis of chronic respiratory disease (CRD) caused by
Mycoplasma gallisepticum and
rate.
The presence of the disease in the group must be established before the veterinary
medicinal product is used.

The recommended dosage rates are:
Pigs: 3.33 mg lincomycin and 6.67 mg spectinomycin/kg bw/day, for 7 days. This
amounts to 15 mg veterinary medicinal product/kg bw/day for 7 days.
Chickens: 16.65 mg lincomycin and 33.35 mg spectinomycin/kg bw/day, for 7 days.
This amounts to 75 mg veterinary medicinal product/kg bw/day for 7 days.
Treatment should be initiated as soon as first clinical signs occur.
The intake of medicated water depends on the clinical condition of the animals. In
order to obtain the correct dosage, the concentration of lincomycin and spectinomycin
may need to be adjusted accordingly.
To ensure a correct dosage body weights should be determined as accurately as
possible.
The use of suitability calibrated measuring equipment is recommended.
Based on the recommended dose and the number and weight of animals to be treated,
the exact daily concentration of the veterinary medicinal product should be calculated
according to the following formula:
mg veterinary
medicinal product / kg
body weight dayx
Average body weight (kg) of
animals to be treated
=
mg veterinary
medicinal product per
litre of drinking water
Average daily water intake (l/animal)
The medicated drinking water should be the sole source of drinking water for the
treatment duration. Only sufficient medicated drinking water should be prepared to
cover the daily requirements. Medicated drinking water should be refreshed or
replaced every 24 hours. The maximum solubility of the veterinary medicinal product
in soft/hard water is 90 g/L at 20°C and 70 g/L at 5°C.
When using a water tank, it is recommended to prepare a stock solution and to dilute
it to the target final concentration. The stock solutions should be replaced every 24
hours. Turn off the water supply to the tank until all the medicated solution is
consumed.
When using a proportioner, adjust flow rate settings of the dosing pump according to
the concentration of the stock solution and water intake of the animals to be treated.
Care should be taken that the intended dose will be completely ingested.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.

Do not use in cases of hypersensitivity to the active substances or any of the
excipients.
Do not use in cases of hepatic dysfunction.
Do not allow rabbits, rodents (e.g. chinchillas, hamsters, guinea pigs), horses or
ruminants access to water or feeds containing lincomycin. Ingestion by these
species may result in severe gastrointestinal effects.
Do not use in laying hens.

Pigs and chickens:
Rare
(1 to 10 animals / 10,000
animals treated)
Irritability, Excitation
Rash, Pruritus
Allergic reaction
, Hypersensitivity reaction
Undetermined frequency
(cannot be estimated from the
available data)
Diarrhea
, Soft stool
, Perianal inflammation
1
Use of the product should be stopped and symptomatic treatment must be
implemented.
Have been encountered

in healthy pigs at the start of the treatment. The symptoms
disappeared within 5 to 8 days without interruption of the treatment.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product.
Reports should be sent, preferably via a veterinarian, to either the marketing
authorisation holder or its local representative or the national competent authority via
the national reporting system. See the package leaflet for respective contact details.

In , a significant number of the strains show high MIC values (minimum inhibitory
concentrations) against the lincomycin-spectinomycin combination and may be
clinically resistant, although no breakpoint is defined.
Due to technical constraints, the susceptibility of is difficult to test in
vitro, and data about the lincomycin-spectinomycin resistance status in that species
are lacking.

Special precautions for safe use in the target species:
It is sound clinical practice to base treatment on susceptibility testing of the bacteria
isolated from the animal. If this is not possible, therapy should be based on local
(regional, farm level) epidemiological information about susceptibility of target
bacteria.
Use of the veterinary medicinal product deviating from the instructions in the SPC may
increase the risk of development and selection of resistant bacteria and decrease the
effectiveness of treatment with macrolides due to the potential for cross-resistance.
The oral use of preparations containing lincomycin is only indicated in swine and
chickens.
Do not leave access to the medicated water for other animals. Lincomycin may lead
to severe gastrointestinal disturbances in other animal species.
The repeated or prolonged use should be avoided, by improving the farm management
and disinfection practices
Diagnosis should be reconsidered if improvement is not seen after 5 days.
Sick animals have a reduced appetite and an altered drinking pattern, and severely
affected animals may therefore require parenteral treatment.
This powder is for use in drinking water only and should be dissolved before use.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Lincomycin and spectinomycin may cause hypersensitivity (allergy) following
inhalation, ingestion or skin contact. Allergic reactions to these substances may
occasionally be serious.
People with known hypersensitivity to lincomycin and/or spectinomycin should avoid
contact with the veterinary medicinal product.
This veterinary medicinal product contains lincomycin and spectinomycin, which may
be harmful to the unborn child. Pregnant women should use this veterinary medicinal
product with caution.
Skin and eye contact with the powder and the medicated drinking water should be
avoided.
This product may cause eye and respiratory irritation.
Handle this product with great care to avoid exposure, taking all recommended
precautions.
Avoid inhalation of dust. Wear either a disposable half-mask respirator conforming to
European Standard EN149 (FFP2 in general, FFP3 for pregnant women) or a non-
disposable respirator to European Standard EN140 with a filter to ENl43.
Wear gloves and safety glasses during preparation of medicated water and wash any
exposed skin immediately after handling the product.
In the event of eye contact, rinse the affected area with large amounts of clean water.
If symptoms such as skin rash, persistent cough, or persistent eye irritation appear
after exposure, seek medical advice immediately and show the package leaflet or label
to the physician.
Special precautions for the protection of the environment:
The use of this product poses a risk to aquatic organisms, terrestrial plants,
groundwater ecosystems and to human health through consumption of groundwater.
To prevent environmental risks, manure from treated animals must not be spread
onto land without dilution with manure from untreated animals. Prior to spreading to
land or trading, one part manure from treated animals should be diluted with at least
three parts manure from untreated animals, and once spread, soil must be ploughed
to a depth of at least 20 cm.
This product should only be used during three production cycles of broilers a year.
The product should not come in contact with water bodies.

The combination of lincosamides and macrolides is antagonistic, due to competitive
binding to their target sites. Combination with anaesthetics may lead to possible
neuromuscular blockade.
Do not administer with kaolin or pectin as they impair lincomycin absorption. If co-
administration is mandatory, observe a delay of two hours between administrations.

Keep the bags tightly closed.
This veterinary medicinal product does not require any special storage conditions.

Pigs:
Meat and offal: Zero days.
Chickens:
Meat and offal: 5 days.
Not for use in birds producing or intended to produce eggs for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.