Libromide 325 mg Tablets for Dogs
Active ingredient: Potassium Bromide
Form
Tablet
Species
Manufacturer
Dechra Regulatory B.V.
VMD MA No.
50406/5025
What it's used for
An anti-epileptic agent for use as an adjunct to phenobarbital in the control of refractory cases of epilepsy in dogs.
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Libromide 325 mg Tablets for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
refractory cases of epilepsy in dogs.
Administer to dogs with refractory epilepsy, where seizure control is unsatisfactory
despite appropriate phenobarbital therapy, when serum phenobarbital
concentrations are at a steady-state within the therapeutic range.
The dose should be titrated to the individual dog as the required dosage will depend
on the nature and severity of the underlying disease.
Administer with food at an initial dose of 15 mg/kg bodyweight twice daily
(equivalent to a total daily dose of 30 mg/kg). Twice daily administration is advised
in order to reduce the risk of gastrointestinal disturbances.
Due to the 24 day half-life of bromide, it can take several weeks or months to
achieve steady-state serum concentrations. For at least the first three months
following commencement of therapy, measure serum bromide concentrations every
4 weeks. The expected therapeutic serum bromide concentration (when used in
conjunction with phenobarbital) is 800 to 2000 µg/ml. Adjustments to the dose
should be made with regard to the frequency of seizures, the half-life of bromide
and the serum bromide concentration. Long term monitoring of serum bromide
Revised: February 2025
AN: 03546/2024
(and associated phenobarbital) concentrations should be performed as clinically
justified by the individual case.
Close monitoring for side effects is advisable at higher serum bromide
concentrations.
Use in dogs with a body weight of less than 11 kg should be subject to a risk/benefit
assessment, see section 4.5.
excipients.
Do not use in dogs with severe renal insufficiency.
exhibit elevated serum pancreatic lipase immunoreactivity concentrations (cPLI)
which may or may not be associated with clinical signs of pancreatitis.
In cases of pancreatitis or dermatitis, symptomatic treatment may be required.
Uncommon adverse reactions also include behavioural changes such as irritability
or restlessness.
Adverse clinical signs which may appear in dogs on higher doses of therapy usually
disappear following a reduction in dose. If the dog is too sedated, assess the serum
concentrations of both bromide and phenobarbital to determine whether the dose of
either should be reduced.
If the dose is reduced, measure the serum bromide concentration to ensure it
remains within the therapeutic range.
Commonly reported adverse reactions include polyuria/polydipsia, polyphagia,
vomiting, somnolescence ataxia (hind end weakness and loss of coordination),
nausea and erythematous dermatitis (bromide rash). In rare cases transient
diarrhoea may occur. Haemorrhagic diarrhoea, pancreatitis, anorexia, hepatopathy,
dyspnoea and vocalisation may appear very rarely.
Revised: February 2025
AN: 03546/2024
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during the
course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
chloride intake on serum bromide concentrations, see section 4.8.
Revised: February 2025
AN: 03546/2024
Special precautions for use in animals
Do not abruptly discontinue therapy as this may precipitate seizures.
In renal insufficiency, excretion of bromide is reduced. To prevent bromide
accumulation, and a relative overdose of potassium bromide (see section 4.10),
administer a reduced dose of Libromide and monitor the serum bromide
concentration closely.
A reduction in chloride intake could cause bromide intoxication (see section 4.8).
Administration on an empty stomach may induce vomiting.
Dogs weighing less than 11 kg cannot be accurately dosed with the recommended
initial dose rate of 15 mg/kg twice daily as the minimum dose achievable by division
of the Libromide 325 mg tablet is 162.5 mg, see section 4.9.
Potentially severe side effects can be associated with the use of potassium bromide
in cats.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Do not handle this product if you are pregnant, think you are pregnant or if you are
breast feeding.
Do not handle this product if you have a known sensitivity to bromide.
Wash hands thoroughly immediately after breaking or handling any tablets.
Discontinue handling this product if you develop any signs of skin irritation, including
itchiness, rash, peeling or flaking of skin or redness. In case of irritation of the skin
or eyes, or in case of accidental self-administration, seek medical advice
immediately and show the package leaflet or the label to the physician.
To the physician:
Bromide intoxication can be treated by administration of sodium chloride or a
suitable chloruretic agent.
chloride (salt) intake will decrease renal re-absorption of bromide, causing
decreased serum bromide concentrations, which could lead to seizures.
Conversely, changing to a diet low in chloride will increase serum bromide
concentrations, which could cause bromide intoxication (see section 4.10).
Loop diuretics (e.g. furosemide) can increase bromide excretion, lowering serum
bromide concentrations.
Administration of fluids or drug formulations containing chloride can lower serum
bromide concentrations.
Bromide is synergistic with other GABA-ergic drugs such as phenobarbital.
Keep the container tightly closed in order to protect from moisture.
pancreatitis may occur in dogs when a high dose is administered.
If overdose is suspected, immediately reduce the dosage. Closely monitor the
serum bromide concentration in order to establish an appropriate therapeutic
concentration.
In cases of overdose, if necessary and appropriate, administer 0.9% sodium
chloride solution intravenously to reduce serum bromide concentrations.
4.11 Withdrawal period(s)
Not applicable.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Potassium Bromide
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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