LETIFEND Lyophilisate and Solvent for Solution for Injection for Dogs
Active ingredient: Recombinant protein Q from Leishmania infantum MON-1
Form
Injection
Species
Manufacturer
LETI Pharma, S.L.U.
VMD MA No.
44009/5000
What it's used for
The efficacy of the vaccine was demonstrated in a field study where dogs were naturally exposed to Leishmania infantum in zones with high infection pressur...
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
LETIFEND Lyophilisate and Solvent for Solution for Injection for Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
naturally exposed to Leishmania infantum in zones with high infection pressure over
a two-year period.
In laboratory studies including experimental challenge with Leishmania infantum, the
vaccine reduced the severity of the disease, including clinical signs and parasite
burden in spleen and lymph nodes.
Onset of immunity: 4 weeks after vaccination.
Duration of immunity: 1 year after vaccination.
A single dose of 0.5 ml to be administered to dogs from 6 months of age.
Re-vaccination scheme:
A single dose of 0.5 ml to be given annually thereafter.
Method of administration:
Reconstitute one vial of the white lyophilisate using 0.5 ml of solvent.
Shake gently to give a clear solution and administer immediately the entire content
(0.5 ml) of the reconstituted product.
excipients.
Very common
(>1 animal / 10 animals treated):
Injection site scratching
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitivity reactions
: allergic skin reaction
(e.g. allergic oedema, urticaria, allergic pruritus)
or anaphylaxis
Lethargy
, hyperthermia
Vomiting
, diarrhoea
1
Spontaneous resolution observed within 4 hours.
Appropriate symptomatic treatment should be administered.
Treatment should be administered as needed.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
The vaccine is safe in infected dogs. Re-vaccination of infected dogs did not worsen
the course of the disease (during the 2-month observation period). No efficacy has
been demonstrated in these animals.
A test for the detection of Leishmania infection is recommended prior to vaccination.
The impact of the vaccine in terms of public health and control of the human infection
cannot be estimated from available data.
Special precautions for safe use in the target species:
De-worming of infested dogs prior to vaccination is recommended.
It is essential that measures to reduce exposure to sand-flies are employed in
vaccinated animals.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Not applicable.
Special precautions for the protection of the environment:
Not applicable.
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by
case basis.
Do not freeze.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Recombinant protein Q from Leishmania infantum MON-1
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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