POM-V Prescription Required

Large Animal Diprevon Solution for Injection

Active ingredient: Diprenorphine

Form

Injection

Species

Deer Horses

Manufacturer

Abbeyvet Export LLP

VMD MA No.

21757/5000

What it's used for

To reverse neuroleptanalgesia induced by etorphine hydrochloride.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Diprenorphine

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Large Animal Diprevon Solution for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

To reverse neuroleptanalgesia induced by etorphine hydrochloride.

A volume equal to the total volume of Large Animal Etorphilon Solution for Injection
injected previously should be given intravenously as soon as possible after the
required period of restraint is complete. Recovery should then take place with
minimal disturbance and noise. Animals should be kept under frequent surveillance
during recovery.
A further half-dose may be used subcutaneously after the initial intravenous dose if
required.

Do not use intramuscularly except in the circumstances of an emergency where
intravenous injection is not possible.
Do not dilute or mix with any other substances.
Do not use in animals intended for animal consumption.

Signs of tachycardia, hypertension and mild tranquillisation may be seen following
remobilisation.
Since the product is used strictly as an antidote, the product literature for the agonist
should be referred to.
Recurrence of excitement, ‘walking’ and ‘head-pressing’ six to eight hours after
remobilisation. These effects may be reversed by a further half-dose administered
subcutaneously.

Animals MUST be kept stabled, protected from extremes of temperature and under
close supervision for at least 24 hours, particularly for the first 8 hours following
administration.
Care must be taken to avoid hypothermia or hyperthermia (see above).
Protect horses eyes from sun or bright light following administration.

i) Special precautions for use in animals
None known.

Revised: October 2025
MA split from NI Expiry following AN 02562/2025
ii) Special precautions to be taken by the person administering the
veterinary medicinal product to animals
Spillages should be dealt with AFTER PUTTING ON SUITABLE HEAVY DUTY
RUBBER GLOVES, neoprene or nitrile of minimum thickness 0.5 mm, using a
copious quantity of water, which can then be flushed down a running sink. Broken
glass should be washed and disposed of in a recognised manner.
The product may induce a hallucinatory state after accidental self-administration.
TO AVOID ACCIDENTAL SELF-INJECTION, the following procedure should be
adopted:
(a) Use two sterile needles, one to fill the syringe from the vial and one to inject the
patient. Once the required dose has been withdrawn from the vial, the syringe
should be removed from the needle. A separate sterile needle should be
inserted into the injection site and the syringe connected to it. Both needles
should be discarded into a closed container.
(b) Wear surgical gloves.
(c) Do not pressurise vial contents.
(d) An eye and skin wash should be readily available for use following any
exposure.
Wash off splashes from skin and eyes immediately.
Should accidental self-injection occur, seek medical advice immediately.
Do not drive.

Do not dilute or mix with any other substances (see section 4.3, Contraindications).

Do not store above 25°C. Protect from light.
Following withdrawal of the first dose, use remainder of the product within one day.
Discard unused material.

Must not be administered to animals intended for human or animal consumption.
Not to be used in horses for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption under
national horse passport legislation.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.