POM-V Prescription Required

Histodine 10 mg/ml Solution for Injection for Cattle

Active ingredient: Chlorpheniramine Maleate

Form

Injection

Species

Cattle

Manufacturer

Le Vet Beheer B.V.

VMD MA No.

41821/4041

What it's used for

For the symptomatic treatment of conditions associated with histamine release.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Chlorpheniramine Maleate

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Histodine 10 mg/ml Solution for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the symptomatic treatment of conditions associated with histamine release.

Intramuscular or intravenous use.
Intravenous injection should be slow and, if necessary, discontinued for a few
minutes (see 4.5).
Adult animals:
0.5 mg Chlorphenamine maleate /kg bodyweight (equivalent to 5 ml/100 kg
bodyweight), once a day for three consecutive days.
Calves:
1 mg Chlorphenamine maleate /kg bodyweight (equivalent to 10 ml/100 kg
bodyweight), once a day for three consecutive days.

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.

Chlorphenamine has a weak sedative effect.

None.

Special precautions for use in animals
Do not administer via subcutaneous route.

Revised; May 2022
AN: 01469/2021 & 01470/2021
Although intravenous administration has an immediate therapeutic effect, it can have
excitatory effects on the CNS. Consequently, administer slowly and interrupt
administration for a few minutes if necessary, when using this route.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Chlorphenamine can cause sedation. Wash splashes from skin and eyes
immediately. Precautions should be taken to avoid accidental self-injection with this
drug. Preferably use a guarded needle until the moment of injection. In case of
accidental self-injection, seek medical advice immediately and show the package
leaflet or the label to the physician. DO NOT DRIVE.

Concomitant use of other antihistamines or barbiturates may boost the sedative
effect of chlorphenamine. The use of antihistamines may conceal early signs of
ototoxicity caused by some antibiotics (i.e. aminoglycosides and macrolides) and
may shorten the effect of oral anticoagulants.

This veterinary medicinal product does not require any special temperature storage
precautions.
Store in the original package in order to protect from light.

Meat and offal: 1 day
Milk: 12 hours

Revised; May 2022
AN: 01469/2021 & 01470/2021
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.