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POM-VPS Prescription Required

Heptavac P Plus Suspension for Injection for Sheep

Active ingredients: Clostridium chauvoei, Clostridium novyi, Clostridium perfringens, Clostridium septicum, Clostridium tetani, Mannheimia haemolytica, Pasteurella trehalosi

Form

Injection

Species

Sheep

Manufacturer

Intervet International B.V.

VMD MA No.

06376/5020

What it's used for

For the active immunisation of sheep as an aid in the control of lamb dysentery, pulpy kidney, struck, tetanus, braxy, blackleg, black disease, clostridial...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Clinical information

Heptavac P Plus Suspension for Injection for Sheep — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the active immunisation of sheep as an aid in the control of lamb dysentery,
pulpy kidney, struck, tetanus, braxy, blackleg, black disease, clostridial metritis
caused by types B, C and D, Cl. septicum, Cl. novyi, Cl.
chauvoei and Cl. tetani.

Revised: January 2025
AN: 02800/2024
The vaccine may be used as an aid in the control of pneumonic pasteurellosis in
sheep of all ages from a minimum age of 3 weeks and in the control of systemic
pasteurellosis in weaned fattening and breeding sheep.
The vaccine may be used in pregnant ewes as an aid in the control of lamb
dysentery, pulpy kidney, tetanus and pasteurellosis in their lambs provided that the
lambs receive sufficient immune colostrum during the first 1-2 days of life.
Onset of immunity: As with most inactivated vaccines, significant levels of immunity
cannot be expected until 2 weeks after the second dose of vaccine in the primary
vaccination course.
Duration of immunity: Evidence of efficacy of the Pasteurella/Mannheimia component
of this vaccine was generated in an experimental infection model and it is not
possible to provide duration of immunity information using this system. There are
reports that active immunity will last for up to 1 year and that passive immunity will
persist for up to 4 weeks after birth in lambs from ewes vaccinated with conventional
Pasteurella vaccines.
None.
Sheep:
Common
(1 to 10 animals / 100 animals treated):
Injection site reaction
.Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypersensitivity reaction,
anaphylaxis
.
Small and transient. Usually characterised by swelling. May be present for up to 3-4
months post-vaccination.
Sometimes fatal. If such reaction occurs, appropriate treatment should be
administered without delay.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
Vaccinate healthy animals only.

Special precautions for use in animals
This vaccine should not be used in lambs less than 3 weeks of age. The nutritional
and metabolic status of pregnant ewes is extremely important at the time of
vaccination. If in doubt, advice should be sought from a veterinary surgeon.
In any group of animals, a small number of individuals may fail to respond to
vaccination as a result of immunological incompetence. Satisfactory immune
responses will only be attained in healthy animals, thus it is important to avoid
vaccination of animals which have intercurrent infection or metabolic disorder.
When handling sheep, stress should be avoided, particularly during the later stages
of pregnancy when there is a risk of inducing abortion and metabolic disorders.
Because sheep are very sensitive to contamination of the injection site (which may
result in non-product related tissue reactions and even in abscesses), it is advised to
follow strict aseptic injection techniques.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Accidental self-injection might result in localized swelling, severe pain, soft tissue
injury or infection.

Revised: January 2025
AN: 02800/2024
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product.
A decision to use this vaccine before or after any other veterinary medicinal product
therefore needs to be made on a case by case basis.
Store in a refrigerator (2 C – 8 C).
Do not freeze.
Protect from light.
Zero days.

Revised: January 2025
AN: 02800/2024
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunologicals for ovidae, sheep, inactivated
bacterial vaccines (including mycoplasma, toxoid and chlamydia), clostridium and
pasteurella.
ATCvet code: QI04AB05.
For the immunisation of sheep as an aid in the control of clostridial diseases and
pasteurellosis.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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