POM-V Prescription Required

EVANOVO Suspension and Solvent for Suspension for Injection for Chickens

Active ingredients: Eimeria acervulina, Eimeria maxima, Eimeria praecox, Eimeria tenella

Form

Injection

Species

Chickens

Manufacturer

Laboratorios Hipra SA

VMD MA No.

17533/5014

What it's used for

For the active immunisation of chickens to reduce clinical signs, intestinal lesions and oocysts output associated with coccidiosis caused by maxima, Eimer...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

EVANOVO Suspension and Solvent for Suspension for Injection for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the active immunisation of chickens to reduce clinical signs, intestinal lesions and
oocysts output associated with coccidiosis caused by
maxima, Eimeria praecox and
Onset of immunity: 21 days of age.
Duration of immunity: 63 days of age in an environment that permits oocysts
recycling.

Revised: August 2025
AN: 04283/2024

In ovo administration.
Vaccination schedule:
Administer one single injection of 0.05 ml or 0.1 ml of the diluted vaccine suspension
into each chicken egg at 18 days of embryonation.
Method of administration:
An automated egg injection machine can be used. In ovo equipment should be
previously calibrated to ensure that a 0.05 ml or 0.1 ml dose is applied. The instructions
for the calibration and use of the equipment should be strictly followed, in order to
deliver the appropriate dose in the amnion of the embryonated egg.
For the dilution and administration of the vaccine, use sterile equipment free from any
residues of chemical disinfectants.
Prepare the required volume of the vaccine as per the examples provided in the tables
below, showing different dilution possibilities, according to different presentations:

Revised: August 2025
AN: 04283/2024
Dilutions for in ovo administration (0.05 ml per dose):
Number and
content of
vaccine vials
HIPRAHATCH
solvent
volume to be
used
Volume of
solvent to be
withdrawn before
vaccine dilution
4 x 1,000 doses 200 ml24 ml2 x 2,000 doses 200 ml24 ml4 x 2,000 doses 400 ml48 ml1 x 4,000 doses200 ml24 ml2 x 4,000 doses400 ml48 ml4 x 4,000 doses800 ml96 ml5 x 4,000 doses1,000 ml120 ml2 x 5,000 doses500 ml60 ml4 x 5,000 doses 1,000 ml120 ml1 x 8,000 doses400 ml48 ml2 x 8,000 doses800 ml96 ml1 x 10,000 doses500 ml60 ml2 x 10,000 doses 1,000 ml120 ml
Dilutions for in ovo administration (0.1 ml per dose):
Number and
content of
vaccine vials
HIPRAHATCH
solvent
volume to be
used
Volume of
solvent to be
withdrawn before
vaccine dilution
2 x 1,000 doses 200 ml12 ml4 x 1,000 doses 400 ml24 ml1 x 2,000 doses 200 ml12 ml2 x 2,000 doses 400 ml24 ml4 x 2,000 doses 800 ml48 ml1 x 4,000 doses400 ml24 ml2 x 4,000 doses800 ml48 ml1 x 5,000 doses500 ml30 ml2 x 5,000 doses 1,000 ml60 ml1 x 8,000 doses800 ml48 ml1 x 10,000 doses 1,000 ml60 ml
Dilution of the vaccine:
1. Withdraw from the HIPRAHATCH solvent container the same millilitres that are
going to be injected of vaccine (EVANOVO), as stated in the example tables
above.
2. Shake the vaccine vial/s and inject the content of it/them into the HIPRAHATCH
solvent container.
Mix the contents of the container by gentle agitation until the contents are
completely diluted.
3. The diluted vaccine is a white suspension, which should be used within 10 hours
after dilution. Mix the container by gentle agitation every 30 minutes during
vaccination.
The vaccine must be injected into the amniotic sac of 18-day-old embryonated
chicken eggs.

Revised: August 2025
AN: 04283/2024
For simultaneous use with GUMBOHATCH, the mixed administration of EVANOVO
and GUMBOHATCH should only be used when vaccinating in ovo 18-day-old
embryonated eggs.
The following instructions should be used:
1.1 Taking into account the HIPRAHATCH solvent container volume, prepare the
EVANOVO vaccine as described above.
1.2 Once the EVANOVO vaccine has been prepared, consider the container volume
to prepare enough GUMBOHATCH doses for the container volume.
1.3 In each GUMBOHATCH vial to be used, insert 4 ml of the EVANOVO diluted
vaccinal suspension prepared in section 1.1.
1.4 Once the lyophilized tablet is properly resuspended, introduce the volumes of the
different GUMBOHATCH vials into the vaccinal container.
1.5 Homogenize by moving the container volume with the hands until having an even
homogenate solution.
1.6 Vaccinate using the vaccinal container with the mixed vaccines within a period of
2 hours via in ovo. Mix the container by gentle agitation every 30 minutes during
vaccination.
Prepare the required volume of each vaccine as per the examples provided in the table
below, showing different mixing possibilities, according to different presentations
in ovo administration (0.05 ml per dose):
GUMBOHATCH
(Number and
content of
vaccine vials)
EVANOVO
(Number and
content of
vaccine vials)
HIPRAHATCH
solvent
volume to be
used
4 x 1,000 doses 4 x 1,000 doses 200 ml2 x 2,000 doses2 x 2,000 doses 200 ml4 x 2,000 doses4 x 2,000 doses 400 ml1 x 4,000 doses1 x 4,000 doses200 ml2 x 4,000 doses4 x 2,000 doses 400 ml2 x 4,000 doses2 x 4,000 doses400 ml4 x 4,000 doses4 x 4,000 doses800 ml2 x 5,000 doses2 x 5,000 doses500 ml8 x 2,500 doses4 x 5,000 doses 1,000 ml2 x 4,000 doses1 x 8,000 doses400 ml1 x 8,000 doses1 x 8,000 doses400 ml4 x 4,000 doses2 x 8,000 doses800 ml2 x 8,000 doses2 x 8,000 doses800 ml4 x 2,500 doses1 x 10,000 doses500 ml1 x 10,000 doses1 x 10,000 doses500 ml5 x 4,000 doses2 x 10,000 doses 1,000 ml4 x 5,000 doses2 x 10,000 doses 1,000 ml2 x 10,000 doses2 x 10,000 doses1,000 ml

Revised: August 2025
AN: 04283/2024
The vaccine should not be used in case its appearance is different from a white
turbid suspension.

None.

None known.

This product is intended for the vaccination of short-lived chickens only. No data are
available on protection of longer-lived birds such as future layers/breeders. The
vaccine will not protect species other than chickens against coccidiosis.
Vaccinate healthy embryos only.

Special precautions for use in animals
Chickens must be strictly floor-reared in the first 3 weeks after vaccination.
In order to reduce field infections, it is recommended that all litter should be removed
and facilities and related equipment in contact with vaccinated chickens should be
cleaned between production cycles.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Wash and disinfect hands and equipment after use.

Safety and efficacy data are available which demonstrate that this vaccine can be
mixed with GUMBOHATCH prior to use and administered simultaneously in ovo. The
product information of GUMBOHATCH should be consulted before administration of
the mixed products.
The mixed administration of GUMBOHATCH and EVANOVO should only be used
when vaccinating 18-day-old embryonated eggs.
For mixed use, the onset of immunity has been demonstrated to be equivalent to those
determined for EVANOVO and GUMBOHATCH when used alone. However, the
duration of immunity following mixed use has not been investigated.

Revised: August 2025
AN: 04283/2024
No information is available on the safety and efficacy of this immunological veterinary
medicinal product when used with any other veterinary medicinal product except the
product mentioned above. A decision to use this immunological veterinary medicinal
product before or after any other veterinary medicinal product therefore needs to be
made on a case by case basis.
No anticoccidial substances or other agents having anticoccidial activity via feed or
water should be used for at least 3 weeks following the hatching of eggs vaccinated
with this product otherwise the correct replication of the vaccine oocysts, and
consequently the development of a solid immunity, could be hindered. Additionally, the
duration of immunity depends on an environment that permits recycling of oocysts,
therefore a decision to use any anticoccidial substances in the period after 3 weeks of
age should be made taking into account the potential negative impact on the duration
of immunity of this product.

EVANOVO suspension:
Store and transport refrigerated (2 ºC - 8 ºC).
Do not freeze.
Protect from light.
HIPRAHATCH solvent:
Do not store above 25 ºC.

Zero days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: Immunological for Aves, live parasitic vaccines for
domestic fowl.
ATC vet code: QI01AN01.
To stimulate active immunity against coccidiosis caused by ,
Eimeria maxima, Eimeria praecox and Eimeria tenella.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.