Euthasol Vet. 400 mg/ml, Solution for Injection

Intravenous injection of pentobarbital has the ability to cause induction excitement in
several species of animal and adequate sedation should be applied if deemed
necessary by the veterinary surgeon. Measures should be taken to avoid
perivascular administration (e.g. by using intravenous catheter).

Revised September 2025
AN: 00869/2024 & 00870/2024 & 01751/2024 & 01752/2024
The intraperitoneal route of administration may cause a prolonged onset of action
with an increased risk of induction excitement. Intraperitoneal administration must
only be used following appropriate sedation. Measures should be taken to avoid
administration into the spleen or organs/tissue with low capacity for absorption. This
route of administration is only suitable for small animals.
Intracardiac injection must only be used if the animal is heavily sedated,
unconscious, or anaesthetised.
To reduce the risk of induction excitement, euthanasia should be performed in a quiet
area.

Special precautions for safe use in the target species:
The intravenous route of administration should be the route of choice and adequate
sedation should be applied if deemed necessary by the veterinary surgeon. For
horses and cattle premedication is mandatory.
Where intravenous administration is impossible, and only following deep sedation,
the veterinary medicinal product may be administered via the intracardiac route in all
named species. Alternatively, for small animals only, administration via the
intraperitoneal route could be used, following appropriate sedation.
In horses and cattle, premedication with an appropriate sedative must be used to
produce profound sedation before euthanasia and an alternative method of
euthanasia should be available.
In the event of accidental administration to an animal not presented for euthanasia,
measures such as artificial respiration, administration of oxygen and the use of
analeptics are appropriate.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Pentobarbital is a potent hypnotic and a sedative, and thus potentially toxic in man. It
can be absorbed systemically through the skin and if swallowed. Particular care
should be taken to avoid accidental ingestion and self-injection. Only carry this
veterinary medicinal product in an unarmed syringe to avoid accidental injection.
Systemic uptake (including absorption via skin or eye) of pentobarbital causes
sedation, sleep, CNS and respiratory depression. Moreover, this veterinary medicinal
product may be irritating to the eye and can cause irritation to the skin as well as
hypersensitivity reactions (due to the presence of pentobarbital). Embryotoxic effects
cannot be excluded.
Avoid direct contact with the skin and eyes, including hand-to-eye contact.
This veterinary medicinal product is flammable. Keep away from sources of ignition.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Avoid accidental self-injection or accidental injection of other persons when
administering the veterinary medicinal product.

Revised September 2025
AN: 00869/2024 & 00870/2024 & 01751/2024 & 01752/2024
People with known hypersensitivity to pentobarbital should avoid contact with the
veterinary medicinal veterinary medicinal product.
Handle the veterinary medicinal product with utmost care, especially pregnant and
breastfeeding women. Personal protective equipment consisting of protective gloves
should be worn when handling the veterinary medicinal product. This medicine
should only be administered by veterinarians and should only be used in the
presence of another professional that can assist in case of accidental exposure.
Instruct the professional if not a medical professional about the risks of the veterinary
medicinal product.
Accidental spillage on the skin or in the eye must be washed off immediately with
plenty of water. If there has been serious skin or eye contact or in the case of
accidental self-injection, seek medical advice immediately and show the package
leaflet or the label to the physician. In the case of accidental ingestion, wash out
mouth and seek medical advice immediately and show the package leaflet or the
label to the physician. But DO NOT DRIVE as sedation may occur.
Information for the health professional in case of exposure:
Emergency measures should be directed toward maintenance of respiration and
cardiac function. In severe intoxication measures to enhance elimination of absorbed
barbiturate may be necessary.
The concentration of pentobarbital in the veterinary medicinal product is such that the
accidental injection or ingestion of quantities as small as 1ml in human adults can
have serious CNS effects. A dose of pentobarbital sodium of 1 g (equivalent to 2.5 ml
of veterinary medicinal product) has been reported to be fatal in humans. Treatment
should be supportive with appropriate intensive therapy and maintaining the
respiration.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Ingestion of euthanised animals by other animals may lead to intoxication,
anaesthesia and even death. Barbiturates are highly persistent in carcasses and also
stable to cooking temperature. Due to the risk of secondary intoxication animals
euthanised with the veterinary medicinal product should not be fed to other animals
but should be disposed of in accordance with national legislation and in a manner
securing that other animals cannot have access to the carcasses.