POM-V Prescription Required

Enzaprost 5 mg/ml Solution for Injection for Cattle and Pig

Active ingredient: Dinoprost

Form

Injection

Species

Cattle Pigs

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/5037

What it's used for

Cattle The luteolytic effect of the veterinary medicinal product can be exerted in the following therapeutic uses: 1. Oestrus synchronisation. 2. Treatment...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Dinoprost

1

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2

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The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

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Clinical information

Enzaprost 5 mg/ml Solution for Injection for Cattle and Pig — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle
The luteolytic effect of the veterinary medicinal product can be exerted in the following
therapeutic uses:
1. Oestrus synchronisation.
2. Treatment of sub-oestrus or silent heat in cows which have a functional
corpus luteum, but do not express behavioural oestrus.
3. Induction of abortion until day 120 of pregnancy.
4. Induction of parturition.

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AN: 02366/2024 & 02368/2024Page 2 of 8
5. As an aid in the treatment of chronic metritis or pyometra where there is
a functional or persistant corpus luteum.
Pigs
1. Induction of parturition from day 111 of pregnancy.
2. Post partum use: reduction of the weaning to oestrus interval (WOI) and the
weaning to fertile service interval (WFSI) in sows with puerperal problems such
as metritis in herds with reproductive problems

Full aseptic precautions should be taken. Use a sterile syringe and needle and
make the injection through an area of clean skin. Care should be taken to avoid
injection through wet or dirty areas of skin.
Cattle
1. Oestrus synchronisation:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per
animal, to be repeated, if necessary after 11 (10 to 12) days.
Animals treated during dioestrus will normally return to oestrus and ovulate within
two to four days after treatment.
Animals treated with the product may be bred by natural service, artificial
insemination on detected oestrus or at fixed time insemination (72 and 96 hours
after the second injection is usually recommended).

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AN: 02366/2024 & 02368/2024Page 5 of 8
2. Treatment of sub-oestrus or silent heat in cows which have a functional
corpus luteum, but do not express behavioural oestrus:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per
animal, to be repeated, if necessary after 11 (10 to 12) days.
3. Induction of abortion until day 120 of pregnancy:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per
animal.
The product may be used to terminate pregnancy in cattle until day 120 of pregnancy
through its luteolytic effect.
4. Induction of parturition:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per
animal on or after day 270 of gestation.
The interval from administration to parturition is one to eight days (average three
days).
5. For the aid in the treatment of chronic metritis or pyometra where there is a
functional or persistent corpus luteum:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per
animal, to be repeated, if necessary after 11 (10 to 12) days.
Pigs
To avoid excessive broaching of the stopper when treating large numbers of
animals using the 50 ml pack size, the use of a multiple dose syringe with a draw-off
needle is recommended.
1. Induction of parturition from day 111 of pregnancy:
One administration of 10 mg of dinoprost (as trometamol), ie 2 ml of the product per
animal within 3 days of expected parturition.
Response to treatment by individual animals varies within a range of 24-36 hours
from administration to parturition. This can be used to control the time of farrowing
in sows and gilts in late gestation. Treatment earlier than 3 days prior to predicted
farrowing date may induce weak piglets.
2. Post-partum use:
One administration of 10 mg of dinoprost (as trometamol), ie 2 ml of the product per
animal 24 to 36 hours after parturition.

Do not treat animals if they suffer from either acute or subacute disorders of the
vascular system, gastro-intestinal tract or respiratory system.
Do not administer to pregnant animals, unless it is desirable to induce parturition or
interruption of pregnancy.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.

Cattle:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hyperthermia
1, 2
Increased salivation
Retained foetal membrane
Injection site infection
1
Transient and not detrimental to the animal.
Disappear within one hour.
If used for induction of parturition and depending on the time of use of the veterinary
medicinal product
May become generalised and be serious. Please refer to section 3.5 (special
precautions for safe use in the target species).
Pigs:
Common
(1 to 10 animals / 100 animals
treated):
Nesting
Very rare
(<1 to 1 animal / 10,000
animals
Treated, including isolated
reports):
Hyperthermia
Injection site pain
Increased respiratory rate
, dyspnoea
Increased salivation
, stimulation of defecation
,
abdominal muscle spasms
, vomiting
Frequent urination
Reddening of the skin
Ataxia
2,3
Anaphylactic-type reaction
Hyperactivity
Pruritus
Nesting is a normal behaviour 5 to 10 minutes after prostaglandin administration in
sows that are housed in pen or pasture.

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Transient: these effects are usually seen within 10 minutes of injection and
disappear within 3 hours. They tend to parallel the signs exhibited by sows prior to
normal parturition, only they appear to be condensed in time.
Slight
Such as restlessness-arching of back, pawing, rubbing and gnawing the crate
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

The veterinary medicinal product is ineffective when administered prior to day 5 after
ovulation.

Special precautions for safe use in the target species:
Localised post injection bacterial infections that may become generalised have been
reported. Aggressive antibiotic therapy, particularly covering clostridial species,
should be employed at the first sign of infection. Careful aseptic techniques should
be employed to decrease the possibility of post injection bacterial infections.
Do not administer by intravenous route.
Induction of abortion or parturition by using exogenous substances may increase the
risk for dystocia, fetal mortality, retention of the placenta and/or metritis.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Prostaglandins of the
bronchospasm or miscarriage.
Care should be taken when handling the product to avoid self-injection or skin
contact.
Accidental spillage on the skin, or accidental eye contact should be washed off
immediately with clean water.
Impervious gloves should be worn to avoid skin contact.
Accidental injection may be a particular hazard to women who are pregnant,
intending to become pregnant, or whose pregnancy status is unknown and to
asthmatics and persons with bronchial or other respiratory problems.
Asthmatics and persons with bronchial or other respiratory problems should handle

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AN: 02366/2024 & 02368/2024Page 3 of 8
the veterinary medicinal product with care to avoid accidental self-injection and skin
contact.
Pregnant women, women of child-bearing age, asthmatics and persons with
bronchial and other respiratory problems should not use the veterinary product or
should wear disposable plastic gloves.
Special precautions for the protection of the environment:
Not applicable.

As non-steroidal anti-inflammatory drugs may inhibit the endogenous prostaglandin
synthesis, concomitant administration of these compounds with the product may
decrease the luteolytic effects.
As oxytocics stimulate the production of prostaglandins, concomitant administration
of these compounds with the veterinary medicinal product, may exacerbate the
luteolytic effects.

This veterinary medicinal product does not require any special storage conditions.
After first broaching the vial, do not store above 25 °C.

Cattle:
Meat and offal: 2 days
Milk: Zero hours
Pigs:
Meat and offal: 2 days

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.