POM-V Prescription Required

Enterisol Ileitis Lyophilisate and Solvent for Oral Suspension for Pigs

Active ingredient: Lawsonia intracellularis

Form

Lyophilisate

Species

Pigs

Manufacturer

Boehringer Ingelheim Vetmedica GmbH

VMD MA No.

61700/3000

What it's used for

For active immunisation of weaned pigs from 3 weeks of age and older to reduce the intestinal lesions caused by Lawsonia intracellularis infection and to r...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Enterisol Ileitis Lyophilisate and Solvent for Oral Suspension for Pigs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For active immunisation of weaned pigs from 3 weeks of age and older to reduce the
intestinal lesions caused by Lawsonia intracellularis infection and to reduce growth
variability and loss of weight gain associated with the disease.
Under field conditions, the difference in average daily weight gain was seen to be up to
30 g/day when vaccinated pigs were compared to unvaccinated pigs.
Onset of immunity: as early as 3 weeks post vaccination.
Duration of immunity: for at least 17 weeks.

All materials used in administering the vaccine must be free of antimicrobials, detergent or
disinfectant residues to prevent inactivation.
Reconstitution with solvent:
10 and 50 dose presentations: Reconstitute the vaccine by adding the full contents
of the accompanying solvent to the vaccine. Shake well and use immediately.
100 dose presentation: Reconstitute the vaccine by adding half of the contents of the
accompanying solvent to the vaccine. Shake well and transfer the suspension back into
the solvent bottle, mix with the remaining solvent to complete to a total volume of 200 ml.
Shake well and use immediately.
Visual appearance after reconstitution: light orange to pink semi-transparent
suspension.
Vaccination by drench application:
Administer a single 2 ml dose orally to pigs (from 3 weeks of age), irrespective of
body weight.
Vaccination via the drinking water:
The systems have to be cleaned and intensively rinsed with untreated water to avoid any
residues of antimicrobials, detergents or disinfectants.
The final solution containing the vaccine should be consumed within 4 hours after
preparation. Calculate the number of vials required to vaccinate all the pigs
according to the table below:
No. of pigs:Vaccine vial:Solvent vial:1010 dose (20 ml)20 ml5050 dose (100 ml)100 ml100100 dose (100 ml)200 ml
Dilute the reconstituted vaccine in drinking water on the basis of pre-measured
water intake during a 4 hour time period of the previous day at the time of planned
vaccination.
Pigs will generally drink 8 to 12 % of their body weight per day, depending on
environmental temperature. The actual amount of water consumed may vary considerably
depending on several factors. It is essential for the efficacy of the product that pigs receive
at least the recommended dose. Therefore, it is recommended to assess the actual water
intake over the 4 hours period the day before vaccination at same time the vaccination is
planned to occur.
In case of vaccination using a trough the total water uptake within 4 hours needs to be
provided. In case of vaccination via proportioner the required volume of stock solution for a
4 hours vaccination needs to be measured.
It is recommended to add skimmed milk powder or sodium thiosulfate solution as a
stabilizer into the drinking water prior to adding the vaccine. The final concentration of the
skimmed milk powder should be 2.5 g/litre. The final concentration of sodium thiosulfate
should be approximately 0.055 g/litre.
After measuring the calculated water amount, sodium thiosulphate or skimmed milk
powder should be added to the water. Afterwards, the reconstituted vaccine is diluted
either in the water / skimmed milk or in the water / thiosulphate mixture.
Ensure that the reconstituted vaccine is evenly distributed in the water. Once even
distribution has been achieved, fill the trough or the proportioner.
Vaccination via liquid feed:
The feeding systems and mixing device must be cleaned to avoid residues of
antimicrobials, detergents or disinfectants.
Calculate the required number of vaccine vials as indicated in the table above.
Determine the amount of feed the animals will consume during one feeding session in less
than 4 hours. The amount of feed should be defined by the feed uptake of the previous
day, at the same feeding session for which the vaccination is planned.
Prepare liquid feed freshly with drinking water. The use of feed with controlled
fermentation or feed containing formaldehyde is not recommended for vaccination as
vaccine stability for these feed types was not tested. Reconstitute the vaccine using the
provided solvent. Add the reconstituted vaccine to the fully prepared liquid feed.
Alternatively, to facilitate homogenous mixing the reconstituted vaccine may be further
diluted to obtain a larger volume. This must be done with fresh drinking water containing
2.5 g/litre skimmed milk powder or 0.055 g/litre sodium thiosulfate and then mixed with the
liquid feed. Ensure that the reconstituted vaccine is evenly distributed into the feed.

None.

Vaccinate healthy animals only.
The vaccine has not been tested in breeding boars.
Therefore, the vaccination of breeding boars is not recommended.
Do not vaccinate animals which are receiving treatment with antimicrobials effective
against Lawsonia spp. Such antimicrobials should be withheld for a minimum of 3
days before and 3 days after the day of vaccination (see section 4.8).
Efficacy of revaccination is unknown.

In case of anaphylactic reactions, appropriate symptomatic treatment including the
administration of glucocorticoids, adrenaline, or antihistamines is recommended.
The vaccine is an attenuated live vaccine and the potential for spreading to non-
vaccinated animals cannot be excluded. However, based on the studies conducted with
sentinel pigs, the apparent frequency of spreading and associated risk is very low.
Lawsonia intracellularis DNA could be detected up to 3 days post vaccination in faecal
samples of more than half of vaccinated animals, therefore transmission to pen-mates
cannot be excluded in this time period.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Avoid accidental contact with the skin. In the event of accidental skin contact, wash with
soap or antibacterial wash and rinse well.

Since the vaccine isolate is a live bacterium, simultaneous use of antimicrobials
which are effective against Lawsonia spp. should be avoided for a minimum of
3 days before and after vaccination (see section 4.4).
No information is available on the safety and efficacy of this vaccine when used
with any other veterinary medicinal product. A decision to use this vaccine before
or after any other veterinary medicinal product therefore needs to be made on a
case-by-case basis.

Store and transport refrigerated (2 °C - 8 °C).
Do not freeze.
Protect from light.

Zero days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group: immunologicals for Suidae, live bacterial vaccines for
pigs,
ATCvet code: QI09AE04
The vaccine is designed to stimulate the development of an active immune response to
Lawsonia intracellularis in pigs.
Seroconversion following vaccination cannot usually be detected, and is not related to
protection.
The vaccine modulates the composition of the microbiome. Published literature suggests
that this can reduce the Salmonella spp. prevalence in the acute phase of the infection and
the seroprevalence at slaughter in L. intracellularis and Salmonella enterica co-infected
pigs.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.