Doramax 5 mg/ml Pour-on Solution for Cattle

For external use only.
Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
- too frequent and repeated use of anthelmintics from the same class, over an extended
period of time.
- under dosing, which may be due to underestimation of bodyweight,
misadministration of the product, or lack of calibration of a dosing device (if any).
Resistance to doramectin and other avermectins has been reported in gastro-
intestinal nematodes, especially Cooperia oncophera and Ostertagia ostertagi
cattle. Therefore, the use of this product should be based on local (regional, farm)
epidemiological information about susceptibility of the target nematodes and
recommendations on how to limit further selection for resistance to anthelmintics.
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. faecal egg count reduction test). Where the results of the
test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to a different pharmacological class and having a different mode of action
should be used.
Do not apply to areas of skin that are contaminated with mud or manure.
Therapeutic efficacy for internal and external parasites is not affected by heavy rainfall
(2 cm in 1 hour) either before (20 minutes) or after (20 and 40 minutes) treatment. The
influence of extreme weather conditions on efficacy is unknown.

Special precautions for use in animals
Avermectins may not be well tolerated in all non-target species. Cases of intolerance
with fatal outcome are reported in dogs, especially Collies, old English Sheepdogs and
related breeds or crosses, and also in turtles/tortoise. Care should be taken to avoid
ingestion of spilled product or access to containers by these other species.
To avoid secondary reactions due to death of Hypoderma
the spine, it is recommended to administer the product at the end of the period of warble
fly activity and before the larvae reach their resting sites. Consult your veterinary
surgeon on the correct timing of treatment.
Disease associated with warble fly is notifiable in some regions.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to the active substance should avoid contact with
the product. Do not smoke or eat while handling the product. Wash hands after use.
The product may be irritating to human skin and eyes and users should be careful not
to apply it to themselves or to other persons. Operators should wear rubber gloves
and boots with a waterproof coat when applying the product. Protective clothing should
be washed after use. If accidental skin contact occurs, wash the affected area
immediately with soap and water. If irritation persists, seek medical attention. If

Issued November 2020
AN: 01572/2018
accidental eye exposure occurs, flush the eyes immediately with clean water and get
medical attention. Avoid accidental inhalation of this product, as this may cause
drowsiness and dizziness. Use only in well ventilated areas or outdoors.
Highly Flammable - Keep away from heat, sparks, open flame or other sources of
ignition.
Other precautions
Doramectin is very toxic to dung fauna and aquatic organisms and may accumulate in
sediments.
The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too
frequent and repeated use of doramectin (and products of the same anthelmintic class)
in cattle.
The risk to aquatic ecosystems will be reduced by keeping treated cattle away from
water bodies for five weeks after treatment.