POM-V Prescription Required

DIVENCE TETRA Lyophilisate and Solvent for Emulsion for Injection

Active ingredients: Bovine parainfluenza virus 3, Bovine respiratory syncytial virus, E2 recombinant protein

Form

Injection

Species

Cattle

Manufacturer

Laboratorios Hipra SA

VMD MA No.

EU/2/24/310/001-003

What it's used for

Onset of immunity: 10 days after vaccination Duration of immunity: 12 weeks after vaccination.

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Prescription required

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Clinical information

DIVENCE TETRA Lyophilisate and Solvent for Emulsion for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: 10 days after vaccination
Duration of immunity: 12 weeks after vaccination.

For 1-dose and 5-dose presentations, reconstitute the vaccine by aseptically adding
the supplied solvent into the vial containing the lyophilised component. Mix well.
For the 10-dose presentation, reconstitute the vaccine in two steps. First transfer a
part of the diluent into the vial containing the lyophilised component. Mix well.
Transfer the mixture into the vial containing the rest of the diluent. Mix well.
Appearance after reconstitution: colourless or yellowish liquid with a slight
opalescence.
Required volume of the reconstituted vaccine is either drawn up from the bottle by
syringe with a needle, the needle is then replaced by the intranasal applicator
provided and the vaccine is administered or left in the bottle and administered via a
multi-dose applicator that can deliver each dose through the intranasal applicator.
The intranasal applicator is used to spray the required volume of the vaccine into
the animal´s nostrils. The applicator used should spray the vaccine in the form of
30 µm to 100 µm droplets.
Vaccination schedule:
Administer one dose (2 ml) of the reconstituted vaccine intranasally (1 ml of the
vaccine into each nostril) to calves from 10 days of age using an intranasal
applicator. It is recommended to use a new applicator for each animal, in order to
prevent the transmission of infection.

None.

Very rare
(<1 animal / 10,000 animals treated, including
isolated reports):
Hypersensitivity reaction*
*may require appropriate symptomatic treatment
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See also the last section of
the package leaflet for respective contact details.

The laboratory efficacy studies have demonstrated that the presence of maternally
derived antibodies at the time of vaccination had no impact on vaccine efficacy in
young animals.
Vaccinate healthy animals only.

Special precautions for safe use in the target species:
Vaccinated calves can excrete the vaccine strains BRSV and BPIV-3 for up to 6 days
after vaccination. Therefore, the spread of the vaccine virus from vaccinated to
unvaccinated calves cannot be excluded. Animals should be vaccinated at least 10
days before the critical period of stress or high risk of infection, such as
rearrangement or transport of animals, or in early autumn. To achieve optimal
results, it is recommended to vaccinate all calves of the herd.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Not applicable.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal products. A decision to use this vaccine before or
after any other veterinary medicinal product therefore needs to be made on a case
by case basis.

Lyophilisate and solvent:
Store and transport refrigerated (2 °C – 8 °C).
Do not freeze.
Protect from direct sunlight.
Reconstituted vaccine:
Store below 25°C. Do not freeze.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.